Sentences with phrase «like macrophages»

Growth or function of different types of immune cells, like macrophages, neutrophils, natural killer cells, T cells, and B cells is impaired by zinc deficiency.

They then showed that when activated, that DNA region, which they called «enhancer # 2» (E2), was capable of switching on Nr4a1 expression only in patrolling monocytes, and not in related cells like macrophages.

This finding suggests that high cellular cholesterol content could push immune cells like macrophages into tumor - fighting mode and presents a very intriguing paradox: namely that inflammation that is deadly in the context of atherosclerosis may be beneficial when it comes to cancer.

The team headed by Thierry Soldati, Professor at the Biochemistry department in UNIGE's Science faculty, has been working on a model system that acts like the macrophages in our immune system: the social amoeba Dictyostelium, a unicellular microorganism.

Mammals keep iron out of reach of invading microbes by storing it in cells like macrophages — white blood cells which, among other things, normally «recycle» the iron from red blood cells back into the bloodstream.

Lacking table manners, these Pac - Man - like macrophages and neutrophils proceed to engulf and consume the uninvited guests.

TLR7 is one of a family of receptors present on innate immune cells like macrophages that have been linked to chronic inflammation and autoimmunity.

A final series of tests confirmed that toxic compounds generated by antibodies kill bacteria without any help from other immune cells, like macrophages.

Not exact matches

He says that some fatty acids look like the bacterial invaders that TLR4 senses, prompting normal macrophages to mistake fatty acids for the enemy and turn on inflammation.

They found that STAT6 - IP prevented RSV - induced changes to airway cells called alveolar macrophages, which can promote asthma - like responses both during and following viral infections.

«This is really the first time that it's been demonstrated that you can use a rapid methodology like this to spatially define cancer cells and macrophages,» Kilian said.

The goal of a therapy like this is to restore the anti-tumor phenotype of macrophages.

Macrophages are the cells within the immune system that ordinarily kill foreign invaders like bacteria and viruses, so without them the gonorrhoea bacteria can flourish.

The innate system — via stem cells in the bone marrow — mobilizes macrophages, which are a type of white blood cell that swallows and kills invading bacteria like Mycobacterium tuberculosis (Mtb) that causes TB.

«Macrophages, the cells that engulf foreign particles and take them out of circulation, like to eat objects that don't require them to expand a lot,» says Mitragotri.

«If macrophages come at one of these wormlike particles from the side, they have to expand a lot to engulf them, and they don't like that.»

Prior research has shown that macrophage migration inhibitory factor (MIF)-- a protein that helps regulate immune and inflammatory reactions — is elevated in people with autoimmune diseases like multiple sclerosis and colitis.

Some macrophage aggregates contained small lipid - like droplets (small thin black arrow).

It's long been thought that white blood cells called macrophages destroy viruses at the site of an infection, like a mosquito bite.

The project began when a post-doc in the Mullins lab, Lillian Fritz - Laylin, collected a time - series of images of macrophage - like immune cells in motion using Betzig's new microscope.

Protective Role of Toll - like Receptor 3 - Induced Type I Interferon in Murine Coronavirus Infection of Macrophages.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

Toll - like receptor signalling in macrophages links the autophagy pathway to phagocytosis.

Macrophages contain toll - like receptors that identify the invaders; when the receptors sense the presence of bacteria, they trigger cathelicidin production.

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

Although macrophages, like dendritic cells, also take up antigens, they are more likely to degrade them than present them to T cells.

Ultimately, Godwin would like to understand why macrophages produced by adult mice and humans don't suppress scarring in the same way as in axolotls and then identify molecules and pathways that could be exploited for human therapies.

Although lipid - mediated atheroma formation and atherosclerosis appear to proceed via pathways distinct from what occurs in MPS I, the roles of macrophages, inflammation, and Toll - like receptors in promoting atherosclerosis are well known [71].

Importantly, the blebs only become bound to cells that are associated with the macrophages at the time of isolation since co-preparation of LN cells from congenically distinct animals did not lead to cross acquisition of macrophage - derived blebs by innate - like lymphocytes from the different LNs (Gray et al., 2012).

The greater CD169 coating of Vγ4 + γδT cells and their stronger dependence on CD169 for retention in the SCS than the other innate - like lymphocytes suggests these cells interact more strongly or in a more selective way with CD169 + macrophages.

These data support the conclusion that S1pr1 acts intrinsically in innate - like lymphocytes to promote close associations with SCS macrophages.

The sugar molecules in reishi mushrooms stimulate the immune system, giving a kick in the pants to immune cells like T - cells and macrophages, whose job it is to attack cancer and other foreign cells.

Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll - like receptor 4.

The immune system is made up of a team of different types of cells that, while each having their own specific function, work together to protect the body from foreign invaders: B - cells produce antibodies; T - cells conduct surveillance for potentially dangerous molecules and kills dangerous cells such as disease - causing bacteria; and macrophages are the scavenger cells of your body acting like garbage trucks, cleaning up residue and removing potentially dangerous substances.

If you like technical explanations, echinacea can increase macrophage activation — by increasing production of interferon gamma.

The microscopic description is usually something like this: hemotoxylin and eosin - stained sections of the mass and adjacent tissue contained irregular lobules of fine mineralized material cuffed by macrophages and multinucleated giant cells....