Sentences with phrase «like mice and humans»

Not exact matches

Much of their work focuses on the house mouse (Mus musculus), which evolved to be commensal with humans: The mice are not domesticated like dogs or sheep, but they are dependent on living in and around a human settlement.

The mice behaved just like others of their kind, as far as scientists could tell, and they also looked the same — except for the human mini brain that had been implanted into each rodent's own cortex, made visible by a little clear cover replacing part of their skull.

They transplanted the hepatocyte - like cells into mice; 14 days later, some of the corrected cells had integrated into the rodent liver and were able to produce human A1AT.

Like the Rosetta Stone that scholars used to decode hieroglyphics, researchers trained the algorithm with more than 4,600 T cell receptors and then used it to correctly assign 81 percent of the human T cells and 78 percent of mouse T cells to one of 10 different viral epitopes.

Sinclair thinks that these mouse models indicate that resveratrol may be effective in preventing age - related diseases in humans, like cancer, heart disease and type 2 diabetes.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

VPA has a known link to autism in humans and also induces autism - like cognitive and behavioral abnormalities in mice.

Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.

Mammalian reservoirs like mice and chipmunks carry Lyme disease and tularemia; ticks transmit these diseases to humans.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.

It's really difficult to get past to work with like mice or rats, and it's really impossible to work with humans.

The result, says Flajolet, is a brain that is hard and transparent, almost «like glass,» which allowed the researchers to see the amyloid plaques in full detail and in 3D, in a full mouse brain hemisphere, as well as in small blocks of human brain tissue.

Like all mammals, including humans, mice lose up to a third of their muscle mass and power as they get older.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

But he cautions that mouse and human livers aren't the same; what's more, whereas Atkins - like diets seem to work in humans because they eat less, mice lose the weight through exercise.

Like the similar - size human population in the surrounding town, each mouse has its own lifestyle and behavior, whether learned or inherited.

This means that its components and functions are similar in diverse species from simple organisms like fruit flies to mice and even humans.

Nevertheless, there are other measures of depression in humans that can be assessed in rodents — like the ability to enjoy pleasurable activities, which is a cardinal feature of depression in humans — you can measure that in a mouse to see how much a mouse likes to eat a sweet treat, have sex, how well it sleeps and so on.

If scientists can figure out how animals like bears, bats, and mice survive the low - oxygen effects of hibernation, D'Allesandro says, it could lay the groundwork for human journeys to not just the mountains — but maybe to Mars.

First author Antonio Di Meco and colleagues used a triple transgenic (3xTg) mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic of the disease in humans.

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six - week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's - like disease, but had no substantive effect on those without the condition.

«However, while these encouraging results in mice mean that the zinc finger looks like a good candidate to take forward to human trials, we still need to do a lot of work first to answer important questions around the safety of the intervention, whether repeat treatments are effective, whether there might be longer - term side effects, and whether we can extend and increase the benefits beyond six months.

The finding, in zebrafish and mice, may have implications for human diseases like multiple sclerosis, in which this insulation is lost.

Mice, like humans, normally secrete leptin after a meal to suppress appetite and prevent overeating.

Now their research has leaped forward: «Research on mice can not directly translate to humans, so we wanted to test if these nanoparticles work on large animals, like dogs, rabbits and monkeys.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

The condition is not only untreatable, but seems to be peculiar to humans, meaning scientists have been unable to study the disease and seek new treatments by modeling it in an animal like the mouse.

And of course there is no uniform strain — thank goodness — of human beings, like there is of mice.

«Just like human breast cancer, there are many subtypes that can be found in mice,» said Eran Andrechek, co-author and physiology professor whose work focuses on the genetic makeup of cancer.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

Results of previous studies in mice of bexarotene's effect on AD have been mixed, and none of those studies were done in mice that carry a human APOE gene and also develop progressive, AD - like pathology.

Comparing levels of S1PR2 in people with MS, mice with a similar disease, and healthy humans and mice, the team found the groups with MS or the MS - like disease had higher levels of the protein, meaning the blood - brain barrier was more permeable.

The mice Shankar used, however, were engineered to be more like humans and could be infected with the virus.

They found that like the mouse cells, these human cells could be maintained in a dividing state and then prompted to differentiate by changing the conditions.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 — have been linked to LCA in humans and mice.

The findings suggest that like (some) humans, mice and other animals may simply exercise because they like to.

Ross says that because the hyperactivity and decreased anxiety might be interpreted as «mania - like» symptoms, the researchers fed the mice either lithium or valproic acid (an anti-seizure drug, also used to treat mania) over a two week period, as is often done in human therapeutic trials.

Now, they've demonstrated that a single amino acid — known by its number along the protein chain, 139 — is the key to this prion protein variant adopting a «human - like» versus a «hamster - like» structure, while another amino acid, 112, governs the structural differences between the human and mouse versions of the protein.

Ralph Brinster, part of the team at the University of Pennsylvania in Philadelphia that first cultured sperm stem cells in the lab, has written that culturing stem cells from human sperm is not far off — humans and mice, like other mammals, he says, require similar growth factors.

Unlike many other cellular and physiological processes, human reproduction varies in significant ways from that of common laboratory animals like mice or fruit flies.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 - have been linked to LCA in humans and mice.

Like humans with AD, hAPP mice have elevated levels of amyloid β (Aβ) peptides in the brain, network and synaptic dysfunction, and amyloid plaques (9).

Much of the bioethics focus has been on what would happen if an animal had enough human brain cells to think and feel like a person — but a person inside the body of a monkey, pig, rat, or mouse.

In their latest research, the Joslin team performed many experiments to explore the actions of these two proteins, called centromere protein A (CENP - A) and polo - like kinase - 1 (PLK1), in mice and in cells from humans and mice.

It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell - like state by introducing combinations of four transcription factors.

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully - human variable regions with intrinsic drug - like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.

To answer basic research questions like these, investigators study bacteria, viruses, fungi, animal cells and human cells (both healthy and cancerous) grown in the lab, and tumors in animals, such as mice and rats.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

But remember, scientists have known for decades that paraquat causes PD - like loss of neurons and symptoms in mice (and humans).