Detlev Arendt and Joachim Wittbrodt, developmental biologists at the European Molecular Biology Laboratory in Heidelberg, Germany, jumped into the fray after Arendt noticed some vertebrate -
like photoreceptor cells in the brains of ragworms, a marine species that hasn't changed much for 500 million years.
Not exact matches
Genetic diseases
like retinitis pigmentosa destroy the photosensitive
cells of the eye, the
photoreceptors, but often leave intact the other
cells in the retina: the bipolar
cells that the
photoreceptors normally talk to, and the ganglion
cells that are the retina's output to the brain.
Human ES
cells treated with Noggin, Dickkopf - 1, and Insulin -
like Growth Factor - 1 proteins differentiate into functional
photoreceptors [5].
A population of these
cells forms a layer deep to the
photoreceptors, where they contain intracellular pigment granules and appear superficially
like an extra RPE layer, even though they do not express at least two characteristic RPE proteins.
The treatment makes these ganglion
cells act
like photoreceptors, responding to patterns of light that pass through the retina and converting them into patterns of electricity that go directly to the brain.