Sentences with phrase «like subpopulation»

Collectively, our results support the idea that a stem - like subpopulation in the tumor could expand selectively in response to changes in the microenvironment.

In our study, we found that the emergence of a small non-adherent subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select for the stem - like subpopulation with the ability to overcome replication arrest whereas the majority of non-adherent cells can not.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Not exact matches

As part of the study, Nikolaus created a chart categorizing which spices were most well - liked, less well - liked, and least well - liked, based on the demographic subpopulations that participated in the study.

She cut that value down to 70 to protect the most vulnerable subpopulations like children.

«The value of a susceptible subpopulation like children,» says Gwen Collman of the National Institute of Environmental Health Sciences, «is that it helps you get away from the mean, which may cloud the truth.

Developmental biologist Goro Yoshizaki of Tokyo University of Marine Science and Technology in Japan and his colleagues set out to see whether spermatogonia — male germ cells that give rise to sperm — might contain a subpopulation of cells with stem cell - like activity that can develop into either sperm or eggs.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

(6) Moreover, subcutaneous adipose of prematurely - aged transgenic mice exhibited high levels of staining for the senescence marker senescence - associated - β - galactosidase (SAβ - gal) and expressed high levels of several established markers of senescence, including p21, p19, interleukin - 6, (insulin - like growth factor binding protein - 2 (Igfbp2), and Pai - 1; primary BubR1H / H; INK - ATTAC mouse embryonic fibroblasts forced artificially into senescence by oncogenic Ras or serial passage exhibited a subpopulation that was both GFP + and stained positively SAβ - gal.

Furthermore, we found that the stem - like and EMT phenotypes observed in the cycling hypoxia - selected subpopulation are not reversible, because we obtained the same molecular profile from this subpopulation by culturing them as spherical cultures for several months in normal oxygen content and culturing them as adherent cells (Figure S2 in Additional file 2).

We also found that cells derived from this novel subpopulation form colonies readily, are highly tumorigenic in immune - deficient mice, and exhibit both stem - like and EMT phenotypes.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.

We hypothesize that SSEA3 expression is either identifying another less differentiated and / or tissue specific stem cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of fibroblasts may acquire the ability to express SSEA3.

The Davis Strait polar bear subpopulation is said to be «vulnerable» to the supposed effects of global warming because, like Hudson Bay, Davis Strait sea ice retreats every summer, leaving polar bears on land for several months.

In some cases, researchers run «simulations based on the minimum size necessary to support local knowledge of subpopulation trends,» said the proceedings, noting that estimates like these «have unknown and in most case inestimable errors.»

Testing for disparities by demographic factors like race and income can suggest a need for policies aimed at reaching out to underserved subpopulations.