Sentences with phrase «like zinc finger»
These approaches, which include exotic sounding tools like zinc finger nucleases and CRISPR / Cas9, differ from more traditional ways reducing the impact of the HD mutation on cells.
https://en.hdbuzz.net/
In the past, researchers have attempted to do this with gene editing tools like zinc fingers nucleases, but the process was too labor - intensive to be used on a large scale.
Not exact matches
«Before CRISPR, there was TALENS [transcription activator - like effector nucleases] and zinc finger nucleases — older technologies that were not as precise or reliable,» explains Sosa.
Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach using this and older gene editing technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.
«However, while these encouraging results in mice mean that the zinc finger looks like a good candidate to take forward to human trials, we still need to do a lot of work first to answer important questions around the safety of the intervention, whether repeat treatments are effective, whether there might be longer - term side effects, and whether we can extend and increase the benefits beyond six months.
There's no reason to think CRISPR would succeed any faster in applications like those, says Dana Carroll at the University of Utah in Salt Lake City, who did pioneering work to develop the zinc finger technology.
The variety of new tools available for genetic manipulation now include lentiviral - based gene delivery, and gene editing using CRISPR / Cas9, zinc finger nucleases (ZFNs) or transcription activator - like effector nucleases (TALENs).
Zinc finger nucleases [1], [2], transcription activator - like effector nucleases [3], [4] and homing meganucleases [5] have provided powerful tools to induce targeted mutations in the form of small insertions or deletions derived from DNA break repair of nonhomologous end joining (NHEJ) or homologous recombination.