To find out if such a gene - environment interaction is involved, they first identified
a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.
By combining those factors, Phevor identifies an undiagnosed disease or the most
likely candidate gene mutation for causing a disease.
Not exact matches
This
gene seemed like a
likely candidate for the mutation since it was only expressed in the skin.
A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «
candidate gene scan» approach — examining SNPs from 42
genes associated with the AHR pathway — also identified AHR2 as a
gene that appears to be under selection and is
likely to be involved in the resistance.
The team pares down a list of about 500
likely causal
genes to slightly more than 200 best «
candidate» autism
genes.
Cystic fibrosis may not be the most
likely candidate for
gene therapy, however, because the disease affects multiple organ systems.
These findings further underscore the utility of the rabbit hybrid zone for fine - scale mapping of
candidate genes likely to be involved in the early stages of reproductive isolation.
Although all seven
genes in the interval are Idd10
candidates, we suggest the
gene encoding the EWI immunoglobulin subfamily member EWI - 101 (Cd101) as the most
likely Idd10
candidate because of the previously reported immune - associated properties of the human CD101 molecule.
One way they have looked for these potential «genetic modifiers,» has been through a
candidate gene approach, methodically hand - picking their most
likely candidates from the 20,000 - some
genes in the human genome.