When the researchers examined mice with disrupted IL - 27 function, they found that they were more
likely than normal mice likely to die when infected with the virus, and that they died as a consequence of rampant lung inflammation.
Not exact matches
In experiments with
mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more
likely to die in the face of rising TNF - alpha signals
than normal cells.
They were also more sensitive to alcohol's effects
than the
normal mice were; studies have shown that the more sensitive a person is to alcohol, the less
likely he or she is to abuse it.
It should be noted, however, that while a study on senescent cell ablation in genetically
normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would
likely show less effect
than could be anticipated in a large mammal model, since even normally - aging
mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to
mice.