Sentences with phrase «limb ischemia»
Limb ischemia refers to a condition where there is a lack of blood flow to a limb, usually an arm or a leg. This reduced blood supply can occur due to narrowed or blocked arteries, which can be caused by various factors like blood clots or cholesterol buildup. When a limb doesn't receive enough blood, it may not get sufficient oxygen and nutrients, leading to pain, weakness, or even damage to the tissues. It is a serious condition that requires medical attention to prevent further complications or loss of the limb. Full definition
«Our results are promising because they show that a combination of gene and cell therapy can improve the outcome in the case of critical limb ischemia associated with aging or diabetes,» says Semenza.
sciencedaily.com
Using a murine hind limb ischemia model, they compared the shape of mouse hind limb blood vessels with those of a patient who had peripheral obstructive artery disease.
We then evaluated whether the encapsulation of hPSC - CDH5 + cells in PA - RGDS could enhance long - term cell survival and vascular regenerative effects in a hind - limb ischemia model with laser Doppler perfusion imaging, bioluminescence imaging, real - time reverse transcription - polymerase chain reaction, and histological analysis.
In other words, evolution has increased the human risk for lower limb ischemia.
«Humans risked limb ischemia in exchange for bipedal walking: A detailed comparison of mouse and human blood vessels with three - dimensional imaging.»
• LimFlow SA, a Paris - based critical limb ischemia solutions maker, raised $ 33.5 million in Series C funding.
A second paper from the same study, which is forthcoming in The Lancet, shows that the same drug combination is superior to aspirin for the risk of losing limbs or severe limb ischemia (limitation of blood flow to a limb), as well as decreasing cardiovascular events, among patients with peripheral artery disease (PAD).
Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice.
For the study, Lookstein's team followed 53 patients with critical limb ischemia who had a total of 94 drug - eluting stents implanted to treat leg arteries that would not stay open after angioplasty alone.
Neovasculogen (VEGF) will be used for treatment of peripheral arterial disease (PAD) and its complication critical limb ischemia (CLI).
The team applied combined murine models of muscle injury and hind limb ischemia to investigate two potential mechanotherapies: an implanted magnetic biocompatible gel and an external, soft robotic pressurized cuff.
Consequently, the mouse vascular structure is more robust against lower limb ischemia than the human vascular structure.
BM - MNCs are another cell population under extensive evaluation in clinical trials for treatment of cardiovascular diseases and for peripheral vascular disease, including critical limb ischemia, as well as for amyotrophic lateral sclerosis (ALS), stroke, obstructive pulmonary disease and more.
The team currently is studying the use of gene and stem cell therapy in mouse models of critical limb ischemia and cutaneous burn wounds.
Dr. Losordo is internationally recognized for his groundbreaking work in the use of gene, protein, and cell therapies to promote new blood vessel growth in patients with peripheral artery disease (PAD) and critical limb ischemia (CLI).
Patients with critical limb ischemia have leg pain even when resting and sores that don't heal because of lack of circulation, Lookstein said.
Critical limb ischemia, the most severe form of peripheral arterial disease (PAD), causes more than 100,000 leg amputations in the United States each year.