Sentences with word «limbal»

Studies have shown that the clinical success of transplantation depends on the number and percentage of limbal stem cells in tissue grafts.

«Previous studies have shown that a threshold percentage of limbal stem cells (which are responsible for replenishing the cornea) is required for successful corneal autologous therapy,» says co-first author Tom Bongiorno, a graduate student in bioengineering at Georgia Tech.

UC Davis offers a DNA test for Haflingers to identify individuals with high risk for limbal squamous cell carcinoma.

Existence of slow - cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells.

The protocol of the product includes Agreement with the doctor, informed consent of the patient, planning for limbal biopsy of the same patient, processing into the ReliNethra ® graft and planning the transplantation in the affected eye.

BrdU fluorescent stainingin a niche of posterior limbal cells spreads to the human corneal endothelium following mechanical wounding.

Nucleic acid and non-nucleic acid - based reprogramming of adult limbal progenitors to pluripotency.

Characterization of putative stem cell phenotype in human limbal epithelia.

Only the center of my iris is brown, the rest is hazel, limbal rings (the edge of the iris) are thick greyish - blue.

Some eye diseases in horses might be genetically linked, as for example limbal squamous cell carcinoma in Haflingers.

Ultraviolet damage might be more extensive in Haflingers (and possibly other breeds) due to a genetic mutation that increases the risk for developing limbal squamous cell carcinoma (SCC).

Similar limbal stem cell transplant work has been done by physicians at the University of Melbourne's Center for Eye Research Australia and the Bernard O'Brien Institute of Microsurgery in Fitzroy, Australia.

For the procedure, which was first performed in 1995, the team harvested the same limbal stem cells that the cornea uses to fix itself and cultivated them on contact lens - like sheets.

Now, in a study published in Stem Cells, the Ahmad group report on the creation of RGCs from adult corneal limbal cells using this methodology, and demonstrate iPSC - derived RGCs to be functional and safe in transplantation experiments [3].

Evaluation of methods for cultivating limbal mesenchymal stromal cells.

Initial reprogramming efforts used adult mouse limbal progenitors (epithelial cells which express Sox2, Klf4, and Myc) which the group reprogrammed to iPSCs using embryonic stem cell CM (ESCM) supplemented with MAPK and GSK3 inhibitors as previously described [4, 5].

classic reprogramming factors makes limbal progenitors an enticing target for ocular therapies.

In Specific Aim 1, we will determine the nature and patterning of limbal innervation.

Researchers demonstrate that autologous oral mucosal epithelial cells expanded under good manufacturing practice requirements can reverse limbal stem cell deficiency in injured eyes up to 24 months, representing an advance in ocular tissue regeneration and transplantation

Differentiation - related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.

ReliNethra ® Transplant is indicated in unilateral partial and total limbal stem cell deficiency conditions like:

ReliNethra ® Limbal transplant leads to renewal of ocular surface epithelial cells thereby replacing the damaged ocular surface with smooth and healthy cells.

Since stem cells have been found to be isolated at the peripheral / limbal region of the epithelium [7 - 9], this study also investigates cell division potential in central and peripheral endothelial tissue.

Since alkaline phosphatase, coupled to the secondary antibody for the BrdU primary antibody, may have complicated the interpretation of the wounding experiments, we also treated human corneal - limbal tissues with BrdU histochemical assays in which fluorescein, rather than alkaline phosphatase, was coupled to the secondary antibody.

They also discovered a DNA marker that identifies horses at higher risk to develop limbal and / or third eyelid SCC.»

The results showed that limbal stem cells were softer, or more easily compressible, than more mature cells.

The epithelial nature of limbal cells, as well as the expression of 3 of the 4 (just lacking Oct4!)

«Future sorting techniques based on cell stiffness and existing biomarkers may enable the enrichment of limbal stem cells, thus facilitating clinical success for patients with naturally low limbal stem cell percentages.»

One major cause of visual loss and blindness is damage to limbal stem cells.

Recently, limbal stem cell transplantation was approved in Europe for the treatment of corneal damage.

Differentiation of human limbal - derived induced pluripotent stem cells into limbal - like epithelium.

Endothelial and limbal tissues were removed by careful stripping with fine forceps to avoid going beyond the most posterior tissues.

In this report, no telomerase activity in the limbal region from Schwalbe's line to the trabecular meshwork was detected.

Further studies may address whether differentiation of these limbal - iPSCs to a non-related cell type provides suitably functional cells, and therefore, if they represent an ideal source for therapeutic purposes throughout the body.

LSCD is caused by the dysfunction of the stem cells within the limbal epithelium, leading to failure of corneal epithelial regeneration.

Limbal epithelial stem cells (LESCs) reside in the basal layer of the limbal area, at the vascularised junction between the corneal and conjunctival epithelium.

Limbal epithelial stem cells sheets cultured on amniotic membranes for treatment of limbal stem cell deficiency (LSCD).

Cellular Component: Limbal epithelial cells Matrix Component: Basement membrane of HAM It is a 4 cm2 denuded human amniotic membrane with cultured autologous limbal biopsy explants with 80 % of the cells positive for p63 marker.

Limbal stem cell transplant results in re-epithelialization of the reconstructed corneal surface.

Although stem cells have been demonstrated to reside in the peripheral and limbal region of the corneal epithelium [7 - 9], our experiments were not able to detect stem cells in the periphery of the corneal endothelium based on the absence of this marker.

It is an autologous limbal stem cell composite graft, prepared from the limbal biopsy excised from the healthy eye of the patient.

Some eye diseases in horses might be genetically linked, as for example limbal squamous cell carcinoma in Haflingers (Lassaline, M.; Cranford, T.L.; Latimer, C.A.; Bellone, R.R. «Limbal Squamous Cell Carcinoma in Haflinger Horses.»

Put a (limbal) ring on it: Women perceive men's limbal rings as a health cue in short - term mating domains.