Sentences with phrase «limited by cancer cells»

Not exact matches

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

VLX600 is a mild inhibitor of mitochondrial respiration, and we have found that dormant cancer cells have a limited possibility to compensate decreased mitochondrial function by increased glycolysis.

The researchers say that the limited success of these drugs could be partly explained by this newly discovered role of integrins within the cancer cell.

While previous research had shown some effectiveness of this molecule in a mouse model of ovarian cancer, that benefit was limited by the immunosuppressive environment within tumors, particularly the presence of regulatory T cells (Tregs).

This two - step strategy would starve cancer cells — which tend to require much higher amounts of energy than normal cells — by limiting their two major pathways for ATP production.

One hallmark of cancer is the accelerated metabolism, high energy requirements, and increased glucose uptake by the tumor cells, the latter being the first and rate - limiting step for glucose metabolism [2,3].

Muehlenbachs said further study was limited by the patient's death and the fact that researchers have been unable to grow tapeworm cancer cells in the lab.

The knowledge about how this cancer form arises and develops is still limited but new results from a research team led by Lene Uhrbom, Uppsala University / SciLifeLab, shows that disease progress and the malignancy are affected by the cell type from which the tumor originates as well as the age of the patient.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therCancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer thercancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer thercancer therapies, and development of better cancer thercancer therapies.

The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].

Cancer cells have developed a number of ways to survive, including ways to escape detection and attack by our immune system, but their ability to respond to viral infections is actually quite limited.

The «claims» are claims for damages and loss for personal injury (limited to chronic obstructive pulmonary disease and / or chronic bronchitis (known together as «non-malignant respiratory disease»), temporary exacerbation of asthma («TEA»), squamous cell skin cancer, lung cancer or bladder cancer) arising out of the employment of the workers named in the group register at various coke ovens owned and operated at various times by British Steel or other companies for whom British Steel have liabilities.