Sentences with phrase «limited efficacy of»

Qing Chen, M.D., Ph.D., and colleagues are particularly interested in brain metastasis, which remains a significant problem in the clinic due to its rising incidence as a consequence of prolonged survival and limited efficacy of existing systemic therapies.

According to researchers, antibiotic resistance and side effects limit the efficacy of the current treatments, which include benzoyl peroxide, retinoids, antibiotics and Accutane (isotretinonin).

Resistance to chemotherapy is a common finding in the clinic, which limits the efficacy of anti-cancer therapies.

Even in «hot» tumors, potent immunosuppressive mechanisms dampen T - cell activity and limit the efficacy of checkpoint inhibitors.

Very short (fs) single pulses improve the photothermal efficacy by minimizing heat loss by NPs, though at the same time they limit the efficacy of PT conversion, since maximal energy is limited by the optical breakdown threshold.

«People who are using four to five layers of skin care are adding so many ingredients that a) it's hard to know what's working, b) it's impossible to know what isn't, and c) the skin can only absorb so much in one sitting so it may limit the efficacy of all products,» said Sarah Villafranco, M.D., founder of Osmia Organics who also happens to have incredible skin.

Persistent hunger and irritability noted in non-obese men and women in earlier IER trials, where food was completely restricted on alternate days, suggest that some individuals are unlikely to be able to comply for extended periods of time.33 Compliance with IER protocols which allow some intake on restricted days have been promisingly high.38, 43, 48, 49, 51, 52 Additionally, several studies have also demonstrated a lack of compensatory hyperphagia 38, 39, 41, 48, 52, 84 upon resumption of free - eating which, if were to occur, would be expected to limit the efficacy of IER as a weight loss / maintenance strategy.

Operator experience also limits the efficacy of combing.

Not exact matches

«The results of our study show that for a well - known brand like eBay, the efficacy of SEM is limited at best.»

I think the last rate cut also showed that the efficacy of the move was more limited than the BoC let on, with most of the net stimulus (through the FX channel) ultimately a function of the projected path for U.S. monetary policy.

When I reflect upon the potential which radical feminist separatism has for change (the introduction of novel forms) into social, political, and economic relationships, I suspect that the intentional political dissociation of women is a form of separatism with limited efficacy.

Having made this correlation, I should add that the hard - core commonsense notions are not limited to elements derivable from perception in the mode of causal efficacy, or what Whitehead also calls physical feelings.

It consists of a highly abstract, derivative, and limited second - order experience consequent upon a more vague and rudimentary kind of perception, which Whitehead terms «causal efficacy.

Nonsensuous perception is certainly not limited to the causal efficacy of the world on or through the sense organs.

Reflecting on the evidence, the study's authors wrote, «Despite the media attention and perceived benefits of these therapies, there are still limited data as to efficacy and long - term safety.

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Available literature on the efficacy of interventions to improve rates of exclusive breast feeding is limited and controversial.

Despite this shift in practice, there are limited data evaluating the efficacy of «nutrient - fortified» donor milk compared with preterm formula.

Its role in the initiation of labour is poorly understood and data examining its efficacy within a clinical trial are limited.

The limited number of marijuana studies are inconclusive regarding the drug's safety and efficacy.

There is no cure for HD and current treatments are of very limited efficacy.

Previous clinical trials of creatine in symptomatic HD patients have been limited in scale, involved daily doses of 10 grams or less, and did not provide evidence of potential efficacy.

«However,» Dr. Dugosh and coauthors add, «there is limited research addressing the efficacy of psychosocial interventions used in conjunction with medications to treat opioid addiction.»

Now they will apply their discoveries to improve the water - use - efficiency of food crops and test their efficacy in water - limited conditions.

I can personally vouch for the efficacy of the 5:2 diet, in which you strictly limit calorie intake two days...

Another treatment, intravenous injection of a clot - dissolving substance, has an even tighter AHA - recommended time limit for efficacy — 4.5 hours — and isn't very effective for treating large clots.

«While oncology teams see the potential of radiosurgery, its novelty means that we have limited prospective evidence of its efficacy.»

Albeit still limited in efficacy, angiogenesis - inhibiting drugs have become part of standard tumor therapy supporting the efficacy of established chemotherapies.

According to Dr. Conroy and co-investigators, most apps use a limited set of BCTs, and developers have favored BCTs with a modest evidence base over others with more established evidence of efficacy.

Despite this shift in practice, there are limited data evaluating the efficacy of «nutrient - fortified» donor milk compared with preterm formula.

Understanding this interaction will lead to targeted treatment «block the interaction» rather than the non-specific dampening of inflammation such as by corticosteroids with its many well - documented side effects and limited efficacy.»

Although these studies were limited to small patient numbers, given the rarity of this disease, PD - 1 pathway blockade seems to have clinical efficacy in mucosal melanoma, with a tolerable safety profile.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Like gold it is a relatively toxic drug that has limited utility due to issues of tolerability and efficacy that is not as robust as other currently available agents.

«Immune checkpoint inhibitors, including PD - 1 and PD - L1 inhibitors, have provided meaningful clinical benefits for patients with cancer; however, novel immunotherapy combination treatments are needed to improve efficacy with limited additive toxicity,» said Aung Naing, MD, FACP, associate professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston.

Efficacy of whey protein supplementation on resistance exercise - induced changes in lean mass, muscle strength, and physical function in mobility - limited older adults.

Since there is limited evidence for harmful effects of a high protein intake and there is a metabolic rationale for the efficacy of an increase in protein, if muscle hypertrophy is the goal, a higher protein intake within the context of an athlete's overall dietary requirements may be beneficial.

Although this preliminary study is demonstrative of the efficacy of the autoimmune protocol, it is limited by its design.

The Food and Drug Administration even recently proposed an upward limit of SPF 50 on labels in order to limit unrealistic claims about the efficacy of certain «ultra,» «mega,» «superstar» sunscreens.

When it comes to learning and evaluating foreign language skills, eLearning has made it easier and more effective but the lack of proper eTesting has limited its efficacy.

Pupils should be taught about the Earth as a source of limited resources and the efficacy of recycling and the production of carbon dioxide by human activity and the impact on climate.

Consider a reasonable, simple, even elegant alternative to replace the vicious circle of narrowed curriculum and comprehension skills of limited efficacy, which over time depress reading achievement.

If we allow children to grow up without limits and without struggle, and exhibit a lack of self - regulation and self - efficacy, they will not persevere.

In sum, the analysis suggests that investment in the professional development of school leaders will have limited effects on efficacy and student achievement unless districts also develop clear goals for improvement.

Research comparing the efficacy of full - day to part - day is limited and some was conducted prior to the Common Core State Standards and other measures holding all students accountable for achieving the same standards regardless of time - in - school models.

Beyond awareness they demonstrated a real desire to try new things but were limited by their own sense of efficacy and time constraints.

Thus the efficacy of culturally relevant pedagogy is not limited to students of color even though the term is most often used to describe effective teaching of racially and ethnically diverse students.

However, there is only limited research on the efficacy of specific mentoring practices and the outcomes of individual programs.

The difficulty in measuring the efficacy of each term on student outcomes, given our current limited assessment models, may be partly to blame.

Although studies in dogs with lymphoma have demonstrated the safety and efficacy of Rabacfosadine (VC - 007), a limited number of dogs have been treated once every three weeks.