Sentences with phrase «limited number of cell»

He observed that normal human cells had a finite lifespan in vitro and could execute only a limited number of cell divisions.

Unlike embryonic stem cells from earlier in development, fetal stem cells from umbilical cord blood are multipotent - they can develop into a limited number of cell types.

Regardless of the source, adult stem cells are multipotent - they can develop into a limited number of cell types.

Pluripotency distinguishes embryonic stem cells from adult stem cells found in adults; while embryonic stem cells can generate all cell types in the body, adult stem cells are multipotent and can produce only a limited number of cell types.

Recent studies highlighted significant differences between these two types of stem cells, although only a limited number of cell lines of different origins were analyzed.

PE: To progress toward cancer, you need a few specific genes to be mutated, within a limited number of cell divisions, to cause the cells to divide uncontrollably.

Not exact matches

In addition to lowering their fees for cell phone service, they also offer free unlimited texting on flights PLUS a free hour of Gogo in - flight WiFi for each flight you take — and there aren't any limits on the number of times you can take advantage of this offer.

In August of last year, President Bush approved the use of federal funds to support research on a limited number of existing human embryonic stem cell lines.

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Last Sunday he announced an end to the limit on the number of books prisoners could have in their cell and allowed families and friends to send in books to inmates.

Eichenbaum cautioned that there are a limited number of brain cells involved in encoding memories that are reused in different ensembles.

If researchers could reduce the loss of cells, they could one day treat two or even three times as many patients from the limited number of cadaver donors available, García noted.

Indeed, although stem cells can divide indefinitely, once they are differentiated, they are locked into a limited life - span, counted down by the number of divisions they undergo.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

As a result, the telomere limits the cell to a fixed number of divisions and a limited life span.

They found that, while the grafts of undifferentiated iPS cells harbored large numbers of T cells of only a few specificities — indicating a robust immune response — those found in grafts of the two types of endothelial cells were more diverse, suggesting a more limited response associated with a phenomenon known as self - tolerance.

Bone marrow biopsies often produce limited numbers of tumor cells to test — as few as 50,000 tumor cells in this study — but for this technique that is enough to test many different drugs and drug combinations.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

«We came up with a way to derive a model of cell behavior, but the approach is complicated and slow, and it is limited in the number of variables that it can track — it can't be scaled to more complicated systems,» Wikswo says.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Telomere shortening limits the number of divisions that cells can undergo.

The limited number of permissible cell lines left, Melton says, can not meet the medical needs of a population as genetically diverse as the human race.

«Is there a limit to the number of stem cell divisions, and does that imply that there's a limit to human life?»

«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells.»

Yet only a small number of egg cells are produced by the female body, so they are the limiting factor in many aspects of reproductive science.

Recharging one of these primary cells could allow the battery to be reused, but the possible number of recharging cycles for such a cell is very limited — it performs more poorly with each recharge.

«Our findings show that nature has a limited number of ways it can cause cells to fuse together into a single cell,» said William Snell, a senior author of the study and a research professor in the University of Maryland Department of Cell Biology and Molecular Genetcell,» said William Snell, a senior author of the study and a research professor in the University of Maryland Department of Cell Biology and Molecular GenetCell Biology and Molecular Genetics.

«We can wake up the virus and then find the rare cells that have been hiding it at very low numbers, a limit of one cell in a million.

Normal cells often have proved impractical because they can only divide a limited number of times in culture, and once returned to the body they're often too old to do much good.

Earlier this year, scientists at University of California, Los Angeles, and Advanced Cell Technology of Marlborough, Massachusetts, reported in The Lancet about the safe and successful use of RPE cells derived from human embryonic stem cells, rather than iPS cells, to treat a different type of AMD in a limited number of human patients.

However, efforts to examine the in vitro behavior of tumor cells with endothelial cells from different anatomical regions have been prohibited because, in large part, of the limited number of organ - derived endothelial cell lines available for study.

In addition, the parasexual cycle is induced between two a / a mating partners when mixed in ménage a trois matings with a limited number of α / α cells that serve as pheromone donors to trigger unisexual a-a reproduction [43].

Tips: Göttgens suggests working with a bioinformatician to design the experiment from the outset to power the study with the right number of cells and to limit the potential influence of batch effects (in which two results differ because they were collected on different days).

The use of viral vectors in research is beneficial for a number of reasons, including but not limited to: helping to get difficult - to - deliver DNA into mammalian cells, increasing the efficiency of gene transduction, allowing for control over which cells are infected through viral pseudotyping, and ease of vector cloning and modification.

Often the feasibility of using stem cells for regenerative therapies is limited by two factors: obtaining a significant number of cells and doing so in a relatively noninvasive manner.

(Progenitor cells are like stem cells in that they can differentiate into different cell types, but progenitors» fates are more limited and they can replicate only a restricted number of times.)

The depth of insight is limited only by the numbers of cells sequenced and cheaper sequencing will enable us to see far back to the early stages of life, and study inter-individual variation in development.

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide.

A limited number of activities will also be directed toward the public to promote the level of understanding for informed decisions and to present the possibilities and problems that surround stem cell therapies for neurodegenerative diseases.

First, while adult stem cells (stem cells isolated from a variety of adult tissues) are limited in their lifespan, hESCs can be grown and expanded indefinitely, potentially creating an infinite number of hESCs from a single human embryo.

How do large numbers of cells, each with only limited local information, collaborate to create something much larger and more complex than themselves?

Western blot analysis of antibody specificity has been done using a routine sample setup composed of IgG / HSA - depleted human plasma and protein lysates from a limited number of human tissues and cell lines.

Human cells undergo a process called cellular aging that limits the number of times they can divide, thereby setting the self - renewal capacity of human tissues.

In addition, work may eventually be allowed on a limited number of stem cell cultures imported from other countries.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

Most human somatic cells can undergo only a limited number of population doublings in vitro.

Cancer cells have developed a number of ways to survive, including ways to escape detection and attack by our immune system, but their ability to respond to viral infections is actually quite limited.

However, due to the limited number of stem cells available, only 10 % of patients referred for cord blood transplantation are eligible, which highlights the crucial contribution of StemCell2MAX for healthcare improvement.

Unfortunately, the body can only sustain a limited number of insulin receptors on each cell.

F cell: An electric fuel cell version of the current five - door B class is being leased to drivers in Southern California in limited numbers for three years.