Most of those findings came from studies in cell
line models of diseases, however.
Not exact matches
The study involved laboratory cell
lines of human leukemia and mouse
models of the
disease.
«The ongoing
line of work with this drug is an excellent example
of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft
models of disease makes possible the clinical trials taking place at the University
of Colorado Hospital next door,» Jimeno says.
The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory
lines of leukemia cells and mouse
models of the
disease.
He hopes the
model will be useful for future predictions along these
lines, such as looking at pathways
of disease progression.
«We compared the ability
of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway
disease — to infect and cause inflammatory responses in a cell culture
model of human epithelial cells, which compose the
lining of the lung airway.
The researchers hope their new cell
lines will be a useful resource for studying the cellular and molecular intricacies
of Huntington's further, and suggest they may provide a
model for examining other
diseases of the brain that are specific to humans.
They show that this new formulation reduces the minimal curative dose in a
disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell
line that is resistant as a result
of mutations in the transporter that mediates drug uptake.
Some ethicists suggest that tissue donors deserve a share
of the tremendous commercial potential
of iPS cell
lines as
disease models, drug - testing platforms or treatments.
We postulate that HD mutant hPSC (embryonic or induced)
lines can constitute such
models and would be key to the exploration
of the molecular mechanisms
of the
disease and ultimately allow the screening
of therapeutic compounds endowed with a therapeutic potential.
Investigating mouse
models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse
lines, importance
of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as well as illustration
of examples
of scientific projects about «Animal
models for human
diseases» and recent developments in mouse
models phenotyping imaging.
Historically, researchers have generated their own
lines of knockout mice to serve as
models for human
disease, such as heart
disease or cancer.
Human primary hepatocytes and immortalized cell
lines (e.g., HepaRG) are used to study these disorders, but due to these cells» high variability, low availability, short assay window, or lack
of physiological relevance, researchers studying metabolic
diseases are searching for more robust and reliable
models.
«Our decision to procure these knockout mouse
lines and data and make them available to the research community will yield tremendous benefits, both in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important mouse
models into the hands
of researchers, speeding advances in the understanding
of human
disease and the development
of new therapies.
Due to the high efficiency
of establishing organoid
models from different tissues and
diseases, such as cancer, organoid technology allows the generation
of large living biobanks
of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell
line and xenograft - based drug studies (7,19).
To create cell
models for the discovery
of disease etiology, progression, and treatment, isogenic cell
lines can be created from healthy or sick individuals, then compared (Figure 1).
Reagents: antibodies, plasmids, cell
lines, RNA libraries, and more Organisms and viruses:
model organisms
of disease, mouse
models, and more Biological specimens Software Protocols Core laboratories eagle - i is different from traditional web publications that list resources (websites, journals, etc.) because the tool allows researchers to: Share resources
NYSCF partners with a broad range
of institutions, foundations, centers and companies in a variety
of ways ranging from the creation
of fundamental research resources such as iPSC
lines for a
disease area to developing human
disease models in vitro to enable drug discovery and toxicity testing.
To better understand this complex tissues and its functions — and the
diseases that affect it — a multicenter team led by researchers at the Broad Institute
of MIT and Harvard and Massachusetts General Hospital has released a census
of the cells that make up the
lining of the small intestine, using gene expression profiles
of more than 53,000 individual cells from the mouse gut or gut organoid
models.
Akassoglou's laboratory uses mouse
models of blood - driven neural inflammation and autoimmunity to explore further the role
of fibrinogen in MS, and she is now pursuing similar
lines of investigation on other neurological
diseases.
The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse
lines, importance
of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as well as illustration
of examples
of scientific projects about «Animal
models for human
diseases» and recent developments in mouse
models phenotyping imaging.
The article describes the generation and characterization
of the TNFΔARE
line, a unique
model that develops both arthritis and Crohn's
disease.
Complementary phenotypic characterization
of a genetically modified animal
model of Parkinson's
Disease:
Line 61 S. RAMBOZ, K. CIRILLO, R. SPRINGER, M. MAZZELLA, M. WINDISCH and K. WALKER... Abstract / Posters
The research
lines of the Bakkers group include unraveling the genetics
of normal cardiac development and body axis formation during development, investigating the molecular mechanisms
of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and
modeling of human (cardiac)
disease in the zebrafish to unravel biological mechanisms behind the
disease and to identify new drug targets.
Speakers will discuss applications
of patient - specific and
disease - specific stem cell
lines, including gene repair (via tools such as the Cas9 nuclease),
disease modeling, drug screening, and regenerative medicine.
By developing a simple chemically defined culture system permitting efficient differentiation
of numerous human iPS cell
lines toward cells
of a mature hepatic state, we now demonstrate the possibility
of modeling groups
of diseases of non-neuronal origin whose phenotypes are a consequence
of complex protein dysregulation within adult cells.