Sentences with phrase «line therapy in»

Review First and Best Treatments for EGFR and PD - L1 - Competition for First Line Therapy in Adenocarcinoma Paul Zarogoulidis, Yan - Gao Man, Wolfgang Hohenforst - Schmidt, Lonny Yarmus, Haidong Huang, Chong Bai, Nikolaos Barbetakis, Christoforos Kosmidis, Chrisanthi Sardeli, Theodora Kerenidi, George Papatsibas, Theodora Tsiouda Oncomedicine 2017; 2: 138 - 141.

Carlos A. Morillo, M.D., F.R.C.P.C., of McMaster University, Hamilton, Canada, and colleagues compared ablation to drug treatment as first - line therapy in patients with paroxysmal AF who had not previously received treatment.

Not exact matches

Novartis set the price for the one - time treatment at $ 475,000, right in line with low - end estimates and one that will put pressure on Gilead to rein in its own price for a rival therapy expected to be approved in the near future.

In discussing the use of ideals and action plans in therapy he emphasized that these need to be «authentic,» that is, in line with the natural development of the persoIn discussing the use of ideals and action plans in therapy he emphasized that these need to be «authentic,» that is, in line with the natural development of the persoin therapy he emphasized that these need to be «authentic,» that is, in line with the natural development of the persoin line with the natural development of the person.

With this distinction in mind some have drawn a line between intervention aimed at somatic cell therapy and intervention aimed at germ cell therapy.

GA was founded in 1957, structured along the lines of Alcoholics Anonymous, the pioneer organization in applying group therapy to fight an addiction.

you could have a point there My dear old dad was having radio therapy last summer and the guy who drove him to his appointments has a 15 year old son in the youth team who quiet freely stated that in the dressing room the rumour is that Theo has lost his bottle and does nt want to injured again.Thing is he was in my opinion NEVER really that good he is great if he has no time to think about his last touch but give him that extra second and he fluffs his lines continuously He is also really really lazy and he really looks like he just cant be bothered and AW giving him a contract extension AND wage increase just shows how far from reality the changing room has become.

Arch Creative and Play Therapy Centre is committed at all times to ensuring children's and young peoples» safety and welfare in line with Children First 2015.

Our Child Safeguarding Statement has been developed in line with requirements under the Children First Act 2015, Children First: National Guidance for the Protection and Welfare of Children (2017), and Tusla's Child Safeguarding: A Guide for Policy, Procedure and Practice as well as with best - practice guidance for Play and Creative Arts Therapists through Play Therapy Ireland / UK.

I also had severe HG for my entire pregnancy (from week 6 to the delivery room), had to go on IV therapy and almost had to get a PICC line put in because it would take 45 minutes to an hour to get a vein each time due the dehydration.

The first - line treatment for the majority of separation anxiety cases is psychotherapy; cognitive behavioral therapy in particular is used with great success on mild to moderate cases.

In the case of mild postnatal depression, therapies will always be recommended as a first line of treatment as long as there are no previous mental health problems or conditions.

I am not a Clinical Psychologist instead I am a Personal Coach that is certified and trained in Humanistic Nuero - Linquistic Psychology, NLP, Time Line Therapy, Emotional Freedom Technique, Hypnotherapy, Age Regression Therapy, Reiki, and other modalities.

He said «Federal Government through the coordinating agency, NEMA and relevant line Ministries, Departments and Agencies have been trying to meet the needs of the IDPs in the provision of food, nutrition, non-food items (NFIs), temporary shelter, medicament, psycho - social therapy, security and protection.

As the first targeted therapies edge towards regulatory approval, attention turns to the next drugs in line.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

But in many cell lines and patient samples that developed resistance to the combination therapy, the researchers observed something different happening.

Whereas the photons used in conventional radiation therapy produced a kind of fog of small clumps of ionization, protons — 2,000 times heavier — left a dense and distinct line of ionization.

The new line of research offers an alternative to helminthic therapy, where people deliberately infect themselves with parasitic worms, in an attempt to put their autoimmune disease into remission.

Dr. Glen Weiss, M.D., M.B.A., is the first author of the study abstract: Phase Ib / II Study of Pembrolizumab plus Chemotherapy in Advanced Cancer: Results of lung cancer patients receiving (at least) 1 prior line of therapy.

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenIn an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin a hypoxic environment.

«The bottom line question,» says Christopher Austin, a neurogeneticist at Merck Research Laboratories in West Point, Pennsylvania, is whether this kind of gene therapy can stem the rate of brain cell death.

Seven years after Moore's initial therapy, Golde asked his patient to sign a contract relinquishing his rights and those of his heirs to any cell lines or products derived from his blood or tissues (Moore's spleen had been removed in the course of his treatment).

Longer follow - up will reveal the durability of these results, the authors said, and may support the evaluation of a first - line approach with ibrutinib and CAR therapy in an effort to remove the need for chronic therapy.

Old - style «behaviour therapies», which came on line in the 1960s, did nothing to combat the social stigma attached to being fat.

Several patients in the ward lay in narrow beds lined up before him, awaiting a treatment called electroconvulsive therapy (ECT).

29 GENETICALLY MODIFIED SUPERHUMANS The debate over human germ - line engineering — reworking genes in the sperm and egg to create inheritable new traits — sputtered out early in the last decade after gene therapy had a series of notable failures.

«The data suggests that state Medicaid policies for access to new hepatitis C therapies should be reviewed and revised in line with national and international clinical recommendations.»

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

In Cohort B — those who received pembrolizumab as first - line therapy — 12 of 52 patients, or 23 percent, saw tumors shrink by more than 30 percent, while the disease was stabilized in nine of them, or 17 percenIn Cohort B — those who received pembrolizumab as first - line therapy — 12 of 52 patients, or 23 percent, saw tumors shrink by more than 30 percent, while the disease was stabilized in nine of them, or 17 percenin nine of them, or 17 percent.

Patients with metastatic colorectal cancer (mCRC) that are mutation - free in the KRAS, NRAS, BRAF and PIK3CA genes showed significant benefit from continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression following first - line chemotherapy and an anti-EGFR monoclonal antibody, according to study results (1) presented today at the ESMO 17th World Congress on Gastrointestinal Cancer in Barcelona, Spain.

In addition, because first - line drugs fail more often than before, more expensive therapies must be used, raising health - care costs.

Now, the researchers will replicate their findings in a larger sample of MS patients, and treat those patients diagnosed with obstructive sleep apnea with positive airway pressure therapy (CPAP), the first - line treatment for OSA.

Commenting on the trial, Dr Alice Shaw, director of thoracic oncology at the Massachusetts General Hospital Cancer Centre in Boston, US, said: «This is the first randomised study to examine how a second generation ALK inhibitor compares to standard second line chemotherapy in ALK positive patients who failed the standard first line therapy, which currently is crizotinib.»

It represents a real advance in the second - line treatment of advanced bladder cancer because pembrolizumab is the first therapy to show a significant survival advantage over chemotherapy for these patients.

«Whilst regulated phage therapy may take some time, it has been highly successful in recent «compassionate» cases where patients» lives were on the line,» said Dr. Forde.

Of the nearly 200,000 men diagnosed with prostate cancer each year in the United States, radiation is a first - line therapy considered for all but the most advanced disease.

Findings from the CONFIRM - HF (Ferric CarboxymaltOse evaluatioN on perFormance in patients with IRon deficiency in coMbination with chronic Heart Failure) trial, presented as an ESC Hot Line and published in the European Heart Journal, point to a simple and safe therapy for a frustratingly common problem, said investigator Piotr Ponikowski, MD, PhD, from Medical University in Wroclaw, Poland.

In line with other trials of a similar nature, drop - out rates were around 20 % and around a third of participants in both groups did not attend the minimum number of therapy sessionIn line with other trials of a similar nature, drop - out rates were around 20 % and around a third of participants in both groups did not attend the minimum number of therapy sessionin both groups did not attend the minimum number of therapy sessions.

A bone marrow transplant is the only standard treatment, but the gene therapy approach, developed by researchers at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy, offers a new line of therapy approach, developed by researchers at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy, offers a new line of Therapy in Milan, Italy, offers a new line of attack.

Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

«This line of work is starting to change our thinking about who and when — the timing and patient selection for anti-androgen receptor therapy in triple - negative breast cancer,» says Valerie Barton, the study's first author and PhD candidate in the lab of CU Cancer Center investigator Jennifer Richer, PhD.

Recently published in the journal Oncotarget, this new study is the most recent in a long line of studies led by Paul B. Fisher, M.Ph., Ph.D., investigating the use of viral gene therapy to treat a variety of cancers.

All patients who responded received only one prior line of chemotherapy therapy, suggesting that the drug may be an option earlier in the treatment course.

In an effort to keep artemisinin resistance at bay, the World Health Organization (WHO) has recommended artemisinin combination therapies (ACTs)-- uniting artemisinin derivatives with bygone antimalarial drugs — as the preferred front - line treatment.

According to Dr. Hsu, nonsurgical therapy should be the first - line treatment in all athletes with lower back conditions because successful recovery rates from rehabilitation protocols are high.

The murky bottom line eased concerns of researchers who have worried that gene therapy, which has been blamed for two deaths in the past 8 years, would be linked to a third.