We only found cells expressing neural markers within the central zone, where many cells were negative for both pluripotency and
lineage specific markers.
Finally, within the fractionated cell populations, there was evidence for coexpression of
lineage specific markers alongside of pluripotency genes, similar to lineage priming described first in hematopoietic stem cells [15].
The lack of co-expression of pluripotency markers and
lineage specific markers at the protein level despite robust co-expression of transcripts of both classes of gene suggests a role for post-translational regulation of expression, perhaps by small RNAs.
As seen in cells dissected from colonies, significant numbers of cells coexpressed
lineage specific markers along with pluripotency genes.
During sabbatical in the laboratory of Chris Tyler - Smith (Wellcome Trust Sanger Center), I genotyped the Y chromosome of HapMap samples with 16 short tandem repeat (STR) markers as well as
lineage specific markers to determine whether the Y chromosome genetic information in this sample was consonant with the purported ancestry of the subjects.
Not exact matches
In the present case, the diagnosis of BPDCN was challenging due to the absence of traditional
lineage -
specific markers and typical cutaneous presentation.
Using this cell line we show that apparently undifferentiated ES cell cultures consist of at least three cell types defined by this
lineage -
specific low - level transcription and the expression of the ES cell
markers Oct4 and Nanog.
Recent observations suggest that there may be
lineage -
specific markers expressed in sub-populations of ES cell cultures.
Studies utilising autosomal, Y chromosomal and mitochondrial DNA
markers in selected Pakistani populations revealed a mixture of Western Eurasian -, South - and East Asian -
specific lineages, some of which were unequivocally associated with past migrations.
Overall, 15 % of cells co-expressed
lineage specific and stem cell
markers.