Therefore, the disease is limited primarily to male dogs due to the sex -
linked mode of inheritance.
Not exact matches
Although the
mode of inheritance is recessive, male dogs born from a carrier female require just one copy
of the mutation, the other gene
linked to the X chromosome from which disease gets its name.
Discovery
of genetic
links and
of the
mode of inheritance (simple or complex, dominant or recessive) is the work
of researchers, but they must have dogs to study.
Epilepsy in beagles was thought to be homologous to Lafora's disease in man based on the similar findings from histopathological examination 23 and the
mode of inheritance was described as autosomal recessive with a sex -
linked «suppressor» 4, 5.
The
mode of inheritance has been determined to possibly be, autosomal recessive in Keeshonds16, polygenic with one gene
of major influence in Belgian Tervurens17, and polygenic recessive in Golden Retrievers.18 Once the
mode of inheritance is determined within a breed, we will determine the best technique to try and find a genetic marker
linked to epilepsy gene (s) in each breed.
In our study
of primary epilepsy, in English Springer Spaniels, Vizslas, and research Beagles the first step will be to determine the
mode of inheritance for each breed (simple recessive, simple dominant, sex -
linked, or polygenic).