Therefore, the description of the first genetic evidence
linking the circadian clock system to energy regulation and metabolism provided a critical step forward for the field, enabling a flurry of biochemical, genetic, molecular, and physiologic studies capable of addressing the underlying mechanisms and pathways.
«Genes discovered
linking circadian clock with eating schedule.»
Not exact matches
Disrupting these
clocks is called
circadian misalignment which has been
linked to metabolic problems even in healthy volunteers.
Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that
links metabolism to the
circadian clock.
The disruption of a person's
circadian rhythm — their 24 - hour biological
clock — has been
linked to an increased risk of breast cancer, according to new University of Georgia research.
Genes with mammoth - specific changes were most strongly
linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and
circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.
With her HHMI money, she will explore the connections between the immune system and
circadian clock genes, as well as the
link between immune response and DNA repair genes.
Much of the body's biological rhythms — when to eat, when to sleep, etc. — are set by a 24 - hour
circadian clock, a biological timing system
linked to the rising and setting of the sun.
«Studies strongly suggest a
link between
circadian clocks, insulin resistance and diabetes development,» explains Charna Dibner, the co-director of the study.
His lab, the largest at the Buck, has diverse projects underway, including: understanding the
link between aging and nutrients, gut function, calcification,
circadian clocks and diabetic complications.
Intriguingly, recent studies have also found a
link between
circadian clocks and metabolism.
Since these findings uncovered a
link between p75NTR and metabolism, the research team tested — first in a petri dish and then in animal models — whether there was also a
link between p75NTR and the
circadian clock.
A possible
link between
circadian clocks, regulation of glucose metabolism, and melatonin signaling in the pancreas was indicated by genetic studies (255).
«This research shows that exposure to environmental toxins may be depressing the function of our
circadian clock, the disruption of which is
linked to increased rates of cancer, diabetes, obesity, heart disease, and depression,» said Jennifer Hurley, an assistant professor of biological sciences, a member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute, and senior author on this research.
Can environmental toxins disrupt
circadian rhythms — the biological «
clock» whose disturbance is
linked to chronic inflammation and a host of human disorders?
«The
circadian clock was not regulating the functions associated with tissue homeostasis but rather functions
linked to the specific stress experienced by each kind of tissue,» Francisca explains.