The Schultz group develops tools for imaging and for manipulating cellular enzyme activities, with a particular emphasis
on lipid signalling in diabetes and the hereditary disease cystic fibrosis.
The fundamental question he raises in his research is
how lipid signaling regulates gene expression and how a changing extra - and intracellular lipid environment impacts the expression of the genome and contributes to changing cellular phenotypes.
Autotaxin -
mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
Burke will receive his award during the 2018 ASBMB Annual Meeting in San Diego, where he will deliver an award lecture on probing the structure, dynamics and regulation of
lipid signaling enzymes in disease.
Currently, Wang said her work is focused on two such metabolite - directed communication systems that regulate metabolic health and longevity: lysosome - to - nucleus
retrograde lipid signals and microbe - to - host metabolite messages.
It is comprised of
lipid signaling molecules called endocannabinoids — which can be thought of as the body's own «natural cannabis» — that bind to cannabinoid receptors located on cells throughout the body.
The annual meeting will have a symposium
on lipid signaling and metabolism, at which JLR Associate Editor Michael Wakelam of the Babraham Institute will give a talk on using lipidomics pathway analysis to identify therapeutic targets.
As a proof of principle, we performed saturation editing of the essential gene SEC14 and identified amino acids critical for chemical inhibition
of lipid signaling.
We will also focus on
lipid signalling and lipid - controlled cell biology, and examine the effect of sphingo - and phospholipids on endocytosis, lipid trafficking, and insulin secretion.
Sphingolipid metabolites, such as ceramide, sphingosine, and sphingosine -1-phospate are
lipid signaling molecules which are involved in diverse cellular processes.
Interdisciplinary science (physics, chemistry, biology), cell biology,
lipid signaling, molecular biology, microscopy