Sentences with phrase «lipid signaling complexes»

The award recognizes his work on the molecular regulation of lipid signaling complexes.

Not exact matches

Even though transient and weak it is becoming more and more obvious that lipid protein interactions are the key for many regulatory processes in which specific protein complexes have to be formed for example upon stimuli during cell signaling.

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.