Sentences with phrase «lipid synthesis»

The liver is the most active site of lipid synthesis.

They previously showed that depletion of HDAC3 in mouse liver upregulates expression of many genes involved in lipid synthesis, which causes a remarkable fatty liver.

The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.

It found that both dietary restriction and rapamycin inhibited lipid synthesis, but only dietary restriction increased the oxidation of those lipids in order to produce energy.

Since lipid synthesis is more costly than carbohydrate production, this parameter has a bearing on the total amount of energy invested by the plant in the maintenance of the symbiosis.

«Knowing how reduced lipid synthesis affects myelination during development is an important step towards gaining a better understanding of how these kinds of diseases progress,» she says.

Recent studies have revealed that the MAM plays a key role in cellular homeostasis, such as lipid synthesis, protein degradation, and energy metabolism.

«Restoring lipid synthesis could reduce lung fibrosis.»

«This is the first paper to show that rather than being a «second hit» to help initiate the disease, blocking lipid synthesis alone — with no other insult to the lungs — can instigate fibrotic scaring,» said Ross Summer Professor of Medicine at Thomas Jefferson University and physician - researcher in the Jane and Leonard Korman Respiratory Institute.

In the ten patients subjected to a restricted diet that involved eating a lower amount of carbohydrates whilst retaining their total calorie consumption, the researchers demonstrated decreases of liver fat, reductions in hepatic lipid synthesis, large increases in markers of lipid breakdown and rapid increases in folate - producing Streptococcus bacteria in the gut.

Insulin actually does activate lipid synthesis, so it can increase fatty acid synthesis and lipogenesis.

This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.

Early effects of dietary orotic acid upon liver lipid synthesis and bile cholesterol secretion in rats, Journal of Lipid Research, Vol 26, 478 - 486, Copyright © 1985 by Lipid Research, Inc..

Firstly, 27 nutritional components were screened in vitro for their ability to up - regulate epidermal lipid synthesis, using cultured canine keratinocytes (Watson et al. 2006).

Treatment with miglustat, an inhibitor of lipid synthesis that is approved outside the U.S. for treatment of NPC, has shown evidence of slowing disease progression.

That has been rather controversial, but the mechanism appears to be that normally insulin does increase lipid synthesis, because it wants to use some of the fuel coming from glucose and other pathways, and help store that energy as fat.

A large number of rare childhood diseases stem from mutations in genes that play an essential role in lipid synthesis.

The Hu laboratory studies endoplasmic reticulum (ER), which has critical functions in lipid synthesis, calcium storage and drug metabolism.

Vitamin B12 is a coenzyme in nucleic acid, protein and lipid synthesis.