Intraspinal treatment was
liposomal cytarabine 50 mg administered by lumbar puncture at day 2 during the four HD - MTX courses.
A total of 200
liposomal cytarabine treatments, (median 4, range 1 — 4) were delivered to 66 patients.
1) Rituximab was added to the induction as the majority of PCNSL are CD20 + diffuse large B - cell lymphomas (DLBCL) and it was previously shown that the addition of rituximab to CHOP chemotherapy has improved the prognosis in DLBCL outside the brain.8 2) The intraventricular MTX / cytarabine treatment of the Bonn protocol requiring an Ommaya reservoir was replaced by intraspinal administration of
liposomal cytarabine in view of the expected lower risk of procedure - related infections.
Not exact matches
CPX - 351 is a
liposomal formulation of
cytarabine and daunorubicin.