Sentences with phrase «liquid organelles»

January 2018 - Princeton University Geraldine Seydoux, PhD, Huntington Sheldon Professor in Medical Discovery and Vice Dean for Basic Research at Johns Hopkins University School of Medicine and HHMI Investigator: «Are RNA Granules Liquid Organelles?

We were able to replicate this process in a biologically - reasonable way in the lab by controlling the electrostatic charge of the molecules that form our synthetic liquid organelles.

«This field is very new and there are likely many different mechanisms by which liquid organelles form in cells, so exploring fundamental questions like «what are the minimum requirements to make these structures come and go as they do in the cell» is very important.»

Because the two molecules have opposite charges, the RNAs and peptides are attracted to one another and self - assemble into droplets that simulate liquid organelles.

This image shows synthetic «liquid organelles.»

The researchers created synthetic liquid organelles by combining, in a solution, negatively - charged RNA molecules with positively - charged short peptides — chains of amino acids similar to, but smaller than, proteins.

Neutralizing the peptides in this manner caused the synthetic liquid organelles to break apart.

«The structures, which we call liquid organelles, often appear and disappear inside cells.

The scientists then reversed this process and the synthetic liquid organelles reformed by adding another type of enzyme, called a phosphatase, which removed the phosphate group from the peptides, reestablishing their positive charge.

Fluorescently labeled, positively - charged peptides (red) are attracted to negatively - charged RNAs (invisible in this image) forming droplets that simulate cellular structures called liquid organelles.

Not exact matches

Recent studies have provided compelling evidence that membrane-less organelles have liquid - like properties and form by liquid de-mixing in a process called phase separation.