Sentences with phrase «little about the mechanisms»

While it has been known that there are considerable differences in how the brain clock of different individuals responds to changing shift cycles, we have known very little about the mechanisms that underlie these differences between people.

While we do have a few theories about why we, and other species we share the planet with, have evolved to grow old and die, we understand very little about the mechanism that makes living cells lose their ability to mend broken and damaged DNA.

Not exact matches

His goal is wildly ambitious — in large part because of how little is really understood about the central nervous system, which consists of the brain and spinal cord, and its healing mechanisms.

To dive a little deeper, we all have a range of mechanisms to update customers about anything new going on in our business.

Next to its peers, Apple also disclosed little information about how it has institutionalized its commitments to users» rights through corporate governance, oversight, and accountability mechanisms.»

I agree with momoya, that it is of little use to make suppositions about such mechanisms or sequences of causation without evidence.

I remember early in my marriage how little I understood about my own arousal mechanism and how uncomfortable we both were when it came to using words to describe our sexual preferences.

«Little is known about the mechanisms that might explain the role of saturated fat intake in obesity,» said Ordovás, who is also a member of the Genetics and Pharmacology & Experimental Therapeutics graduate program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University.

Despite its relevance, little is known about the precipitation mechanism of calcium carbonate, and specified complex crystal structures challenge the classical view on nucleation considering the formation of metastable ion clusters.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.

Most research exploring patterns of species survival has focused on birds; little is known about the physiological mechanisms that allow mammals to survive in urban environments.

So far, little was known about the molecular mechanisms connecting squamous cell carcinomas and RDEB.

They say this latest study raises questions about whether treatments that decrease the frequency or severity of migraine may reduce later life vascular risks, and conclude by saying «what little evidence we do have suggests the need for therapeutic restraint [to prevent cardiovascular risk] until we have a better understanding of the mechanisms underlying the link between migraine and vascular disease.»

«Despite the importance of a proper «work - rest balance» for HSCs, we know amazingly little about the molecular mechanisms controlling this,» said Sauer.

While there is general consensus that the ability to imagine a never - before - seen object or concept is a unique and distinctive human trait, there is little that we know about the neurological mechanism behind it.

Furthermore, Britton said, little is known about the neurobiological mechanisms of these experiences.

However, still too little is known about the precise mechanism behind incretin release.

However, little is known about brain mechanisms related to dental pain relief.

In early 2012, Emmanuelle Charpentier, a little - known French microbiologist who would soon meet worldwide fame, contacted her old friend Rodger Novak to tell him about her recent studies at Umeå University in Sweden of the mechanisms behind a novel bacterial immune system.

But while extreme rainfall has been rising, little was known about the mechanisms causing it.

Little is known about the exact molecular mechanisms by which Klotho suppresses aging.

To date, there are no cures available for PH. Little is known about the mechanisms underlying these diseases, an understanding essential to development of therapeutic strategies.

Despite profound sex differences in the expression of social behavior and the incidence of these psychiatric disorders, little is known about how the brain mechanisms underlying these phenomena differ in females and males.

The primary finding and «surprise,» said Mackey, is how little is known about the precise scope of the problem and how few mechanisms exist to monitor it despite the availability of some data.

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

Human melanoma is a very aggressive skin cancer, but very little is known about the mechanisms that cause the disease to progress.

Non-celiac gluten sensitivity affects around six times more people than celiac disease, according to the National Foundation of Celiac Awareness, yet relatively little is known about the mechanisms that cause it.

Although drugs like Prozac, which increase levels of the neurotransmitter serotonin, seem to help some people, little is known about the mechanisms behind the disorder.

Relatively little is known about the underlying mechanisms that lead to the cognitive and learning deficits in fragile X syndrome, Zhao says, making it difficult to devise effective therapies.

It is possible that exercise results in migration from subcutaneous habitats to the skin surface, but little is known about this potential mechanism.

So far, we know very little about the underlying neuronal mechanisms of these navigation problems,» says Matthias Stangl, a researcher at the DZNE's Magdeburg site and first author of the current publication.

Little is known about the underlying mechanisms of this deficit in facial affect recognition, which may contribute to social dysfunction.

Despite similar techniques across cultures and powerful phenomenology, little is known about the mechanisms underlying trance.

Little is known about the mechanisms that cause age - related neuronal degeneration and death.

While core pathways for BR metabolism and signaling have largely been defined, little is known about the molecular mechanisms regulating BR homeostasis and how these in turn modulate plant development.

«We know very little about how A. tumefaciens causes disease in humans, but the mechanism of disease does not appear to be the same in animals and plants,» says Goodner, now of Hiram College in Ohio.

«We know relatively little about the behavioral or ecological mechanisms that allow these induced defenses to be effective,» says Richard Karban, an ecologist at the University of California, Davis, who was not involved in the work.

Mechanisms have been sought to explain this process of regeneration polarity for over 100 years, but until now, little was known about how planaria can regenerate heads and tails at their proper sites.

Vesicle Traffic Late in the Secretory Pathway Little is known about the mechanism of sorting and packaging of secretory proteins that transit from the Golgi complex to the cell surface.

However, little is known about such mechanisms.

Whereas there has been extensive work on the neural mechanisms that subserve voluntary limb movement, comparatively little is known about how the motor system modulates the mechanical properties of the limb through the neural control of limb stiffness.

While we now have a detailed account of post-copulatory mechanisms in web - building spiders, we still understand very little about pre-copulatory courtship, its function, mechanism or evolution [10].

Although there is substantial evidence from neuroimaging studies that the brain of a child with autism is undergoing abnormal development, little is known about the underlying cellular, molecular and genetic mechanisms that lead to the onset of autistic symptoms.

The VCC nature and origin remain elusive and very little is known about the molecular mechanisms allowing viral assembly and production.

Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health but relatively little has been known about the mechanisms of tumorigenesis involved.

Very little is known about how formation of these complexes is regulated, or the mechanisms through which Oct4 proteins respond to complex extracellular stimuli which regulate pluripotency.

However, little is known about the mechanisms by which hypothalamic neural circuits controlling behavior and metabolism sense protein availability.

Little is known about the mechanism of translational activation of translationally repressed mRNAs.

«In fact, chronic itch is a disease of the nervous system manifested in the skin, but we understand very little about basic mechanisms and effective treatments.»