Sentences with phrase «live imaging approaches»

By using novel live imaging approaches and mammalian genetics we investigate the dynamic coupling of growth and morphogenesis during skull tissue development.

To this end we use quantitative live imaging approaches as well as super-resolution methods.

The new live imaging approach was developed by a team of researchers at the University of Miami (UM).

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

Not exact matches

Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID) have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

The significance of the team's approach is that it «enables imaging of live cells in a high - throughput manner at a time resolution at which all biologically relevant dynamics appear static,» he said.

Using a combination of molecular biology, biochemical and novel multi-dimensional digital imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.

These questions will be addressed by combining unbiased «omics» - approaches (i.e. genomics, transcriptomics, and proteomics) and a targeted genetic analysis with both superresolution live - cell imaging and electron microscopy of nanotube - forming cells.

new technological advances in the field of live imaging [e.g. magnetic resonance imaging (MRI) and optical in - vivo imaging] to develop new preventive and / or therapeutic approaches for these diseases.

We exploit chick and mouse embryo animal models, combined with live imaging, cell and tissue cultures and molecular approaches.

Using single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.»

Since biological systems challenge the available methods, and the necessary foundations in physics, computer science, and mathematics are often missing, the CellDevo track greatly benefits from the fundamental research in computer science, bio-image informatics, biophysics, and applied mathematics represented in the CompBio and BioPhysEng tracks and help to develop the methodological foundations for future biology in tight integration with life imaging and other experimental approaches.

We are using live imaging, transgenic reporters of osteoblast gene expression and targeted RNAseq approaches to identify the molecular regulators of progressive osteoblast differentiation during expansion of the skull.

For this we use gene replacement, live and fixed cell imaging, conditional localization and (in) activation approaches, proteomics, biochemistry and structural biology.

By applying biophysical techniques to elucidate the overall shape of ALC1 and combining these approaches with cell - based and live - cell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domain.

«This experimental approach appears to combine the most attractive element of treatment, eradication of the cancer, with the most appealing element of active surveillance, maintaining quality of life,» said Aytekin Oto, MD, professor of radiology and chief of abdominal imaging at the University of Chicago Medicine.

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

We address these questions by combining genetics with live imaging, quantitative image analysis and biophysical approaches using the fruit fly Drosophila melanogaster as a model organism.

To come to a structural understanding of nuclear organisation, we will explore and further improve correlative imaging approaches, combining live cell confocal microscopy, super-resolution and electron tomography to unravel the structure and mechanisms of NPC assembly and disassembly.

In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animal.

We are studying chromatin organisation and compaction, as well as the 4D human genome architecture by correlative imaging approaches, including live cell imaging and various super-resolution techniques (figure 2).

The Innovator Award will enable Sipkins to continue to combine state - of - the - art imaging techniques, performed on living mice, with cell and molecular biology approaches to learn more about these stem cell niches.

Aim 3: We are specifically interested how defects of nuclear proteins cause axonal phenotypes using live cell imaging techniques, inhibitor studies, laser irradiation, - omics approaches.

To pursue these studies, we employ Hi - C and ChIA - PET genomic technologies and single locus / live - cell imaging approach.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

While Mr. Hwang already confirmed LG is taking a different approach to the development of the G6 successor, he now elaborated on the matter by disclosing the firm's mobile team is focusing on four specific areas: displays, audio performance, battery life, and imaging capabilities.