Hybridising between
live vaccine strains, or a live vaccine and wild viruses, is less predictable.
Not exact matches
The scientists believe that because they included eight mutations in their lab - made viral
strain, it is unlikely the virus will revert back to its original, more dangerous form (a common concern with any
live - virus
vaccine).
Both
vaccines were based on
live, weakened
strains of polio virus grown in monkeys» kidney cells.
In addition,
vaccine - makers that use eggs can not begin developing new
vaccines that target new virus
strains until the U.S. Centers for Disease Control and Prevention (CDC) creates a
live - virus reference
strain for these companies to work with, a process that could take several weeks.
He worries that a
live vaccine that uses Vibrio
strains whose virulence genes have been removed may still be capable of getting new virulence genes through its integron.
Then they began using a third
live vaccine containing a European
strain.
Chicken farmers in Australia were using two
live vaccines, both made from Australian viral
strains, against a poultry disease called infectious laryngotracheitis (ILT).
These rare VDPVs arise when a virus used in the
live vaccine reverts from its weakened form and regains its virulence — a danger when vaccination rates are low, as they are in both places, allowing the
vaccine strain to circulate and accumulate genetic mutations.
Because Ebola is so deadly, creating a conventional
vaccine of inactivated whole virus, or a
live weakened
strain is thought too far too dangerous.
But two new
strains of a nasty poultry disease that have been plaguing chickens in Australia since 2008 have been found to be hybrids of viruses from
live vaccines.
They then began using a third
live vaccine containing a European
strain.
«This work shows that with
live vaccines, we need to pay attention to the evolution of the
vaccine strains themselves,» says Andrew Read at the University of Pittsburgh in University Park, an expert in pathogen evolution who was not involved in the research.
GMT for the BPV
vaccine and
live virus were not different for the two
strains p >.05.
However, they said the development of the
vaccine was timely, amid concerns the H5N1 bird flu
strain circulating in south east Asia could mutate into a pandemic
strain which would put millions of
lives at risk.
Even though the flu
vaccine was only 25 percent effective against the severe H3N2
strain that caused the most illness, the
vaccine could have been even less effective and still saved tens of thousands of
lives, the researchers said.
The
vaccine can contain one of two things, a
living, non-harmful
strain of the bacteria or virus that you're safeguarding against or a nonliving, inactive version that can replicate itself in the body.
The FIV
vaccine is one that will cause the cat to test positive for the rest of its
life, but doesn't offer immunity to all
strains of the virus so we don't recommend giving it.
Distemper
vaccine reactions can also involve neurological signs, especially if the
vaccine contains modified
live virus — the Rockborn
strain of virus — that is known to produce post-vaccinal encephalitis.