Sentences with phrase «lived effector»

Consistent with prior reports on effector cells (35), we observed that, among CD8 + T cells specific for the dominant epitope of LCMV (GP33), the percentages of short - lived effector cells (KLRG1 + CD127 −) were increased, and the percentages of memory precursor cells (KLRG1 + CD127 +) were decreased in the peripheral blood of DGKζ − / −, Cbl - b − / −, and DKO mice relative to WT mice after acute infection (Fig. 5A).

Six weeks postinfection, splenocytes were analyzed for gp33 - LCMV — specific total CD8 + T cells (B) or short - lived effector cells and memory precursor effector cells (C).

DKO mice, however, have a decreased percentage of memory precursor cells and an increase in short - lived effector cells compared with WT mice.

They include reduced lymphocyte repertoire, increasing clonality and increasing autoreactivity.5, 7,8 Recent work has focused on intrinsic cell defects, which alter T cell activation threshold, induction of cellular senescence and differentiation into short - lived effector or long - lived memory cells.

Not exact matches

The attraction of large - scale compound screening for life science researchers lies mainly in the technical challenge of assay design and the use of small - molecule effectors for hypothesis - driven research.

It is worth noting that «academic drugs» need not be blockbusters and that most life sciences rely heavily on small - molecule effectors (e.g., A23187, phalloidin, or phorbol ester).