Sentences with phrase «liver cells using»

To test the quality of the «blood vessels» produced, the researchers cultured a chunk of tissue made from rat liver cells using their technique.

Not exact matches

The short - chain fatty acids that aren't used by the cells in the colon travel to the bloodstream, liver and to the rest of the body, where they may lead to various beneficial effects (19, 20).

Large quantities of these reverted cells could be used to treat anything from spinal cord injury to liver damage without the risk of tissue rejection, said Robert Weinberg, a biologist at the Massachusetts Institute of Technology's Whitehead Institute for Biomedical Research and co-author of a study appearing in Cell.

«Using these new cells we might achieve organ acceptance in liver transplants, without touching the remaining immune system,» says co-author Luis Graca.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

After watching those mice thrive for several months, Lagasse repeated the experiment using fluorescent markers to trace the path of the liver cells.

The researchers used the dead guide RNAs to turn on the Pdx gene in the mice's livers, which caused the liver cells to produce insulin, reversing the mice's diabetes.

U.S. biotechnology company Circe Biomedical has had similar success, she said, showing in an ongoing clinical trial of a similar device using pig liver cells that six out of 36 patients have completely recovered without the need for transplant.

Among the many approaches they took, the researchers generated induced pluripotent stem cells (iPSCs) from the SCARB1 - deficient person, used them to create liver cells, and showed these new cells had profound reduction in their ability to take up HDL.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

Chien Ho, professor of biological sciences at Carnegie Mellon University, and his colleagues have developed a novel way to improve delivery of chemotherapy nanodrugs by using Intralipid ®, an FDA - approved nutrition source to temporarily blunt the reticuloendothelial system — a network of cells and tissues found throughout the body, including in the blood, lymph nodes, spleen and liver, that play an important role in the immune system.

The current research suggests that pancreatic cancer cells that spread to organs that receive a blood supply rich in glucose and other nutrients, such as the liver and lungs, acquire metabolic adaptations to use these «natural resources» to increase their tumorigenic fitness.

The researchers have used a similar procedure previously to create heart, brain, and liver cells.

The study also examines the use of lentiviral vectors for cell delivery in treating liver diseases, a tool traditionally used in treating blood disorders.

«The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sicell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount SiCell Institute, at the Icahn School of Medicine at Mount Sinai.

A team of multidisciplinary researchers with expertise spanning biotechnology, information technology, and medicine have used a combination of several «omics technologies to map proteins down to the single cell level, showing both proteins restricted to certain tissues — such as the brain, heart, or liver — and those present in all tissues.

And by creating personalized organoids from the reprogrammed cells of patients, scientists could study disease in a very individualized way — or maybe even use organoid structures to replace certain damaged tissues, such as in the liver or spinal cord.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.

They're not developed enough to function as liver transplants, but the cell clusters do have important uses, says McGuckin.

It therefore makes sense to use liver cells to test the toxicity of substances.

When you're using certain tissue types that can't replicate multiple times outside of the body — liver and nerve cells, for example — «that's where stem cells are most relevant.»

Using stem cells from umbilical cord blood, researchers are growing clusters of real liver cells in the lab.

One of the most promising approaches involves the use of cultured liver cells.

A microreactor developed as part of an EU - funded collaborative research project enables cultured liver cells to be used as test samples.

Normally, people who are overweight face a greater risk for insulin resistance, a condition in which the body does not use insulin effectively to shuttle glucose into liver, fat, and muscle cells.

In a paper published in the journal Proceedings of the National Academy of Sciences, Sangeeta Bhatia of MIT and Charles Rice of Rockefeller University describe using microfabricated cell cultures to sustain hepatitis B virus in human liver cells, allowing them to study immune responses and drug treatments.

One uses primary hepatocytes obtained from livers donated for transplant; the second uses stem cells derived from human skin samples and guided into hepatocyte - like cells, Bhatia says.

Researchers from the University of Surrey (UK), the Federal University of São Paulo and the Butantan Institute in Brazil used an innovative 3D liver cell examination to explore the liver function of this snake - like amphibian.

For example, if the process were used to create liver cells for a drug test, the resulting product «would actually have vascularization in it that is modeled on how a liver works.»

Because cancer cells grow and divide rapidly, they use a lot of energy, sucking up glucose and giving themselves away; the red coloring denotes disease in the patient's liver and shoulder area.

A surgical ultrasound device is used that was previously used for liver cell carcinomas.

Using patient - derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung / liver disease called alpha - 1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease.

To trace the lineage of liver cells, scientists used a telltale marker — the cells» response to signals delivered by a known stem - cell regulator called Wnt.

As the researchers showed, the rate of vesicle formation, and hence the uptake of excess bile into liver cells, can indeed be adjusted using drugs, at least in the cell culture setting.

To investigate how the liver responds to bile accumulation, the research team used an artificial culture system, which allowed the easy manipulation of cultured liver cells.

Using these techniques, we were able to show polyploid liver cells protected the liver against cancer formation in the mouse,» said Dr. Hao Zhu, Assistant Professor at CRI and a CPRIT scholar in Cancer Research.

In an elegant proof - of - principle approach, the researchers used synthetic molecules to decrease the physical distance between the ER and mitochondria in cells and in liver tissue and found that this intervention impaired mitochondrial function and made mice more sensitive to high fat diet - induced insulin resistance and diabetes.

In order to determine which type of liver cells cause this accumulation, the researchers repeated the experiment using cultured hepatocytes.

The researchers used electron microscopy and other imaging techniques to view thousands of cells from the liver tissue of lean and obese mice.

Using a novel method — design - based stereology — which enabled researchers to estimate the volume of the liver and the total numbers and sizes of its cells in 3D, it was found that the liver of mice on a low protein diet had decreased by 65 %.

Geneticist Yoav Gilad of the University of Chicago and his colleagues used a new technique to examine the genes in the liver cells of four primates: humans, chimpanzees, orangutans and macaques.

Using an animal model, they found that TIMP - 1 recruits immune cells by increasing the levels of a specific signaling molecule in the liver.

He says that it may soon be possible to take healthy liver cells from a patient whose liver is failing and use them to make tissue that would be stored in the laboratory.

An international team led by metabolism experts Matthias Tschöp (Helmholtz Zentrum München / Technische Universität Müchen), Richard diMarchi (Indiana University) and Timo Müller (Helmholtz Zentrum München) report in the current issue of the journal Cell that liver - specific delivery of the thyroid hormone T3 using glucagon corrects obesity, glucose intolerance, fatty liver disease and atherosclerosis without causing adverse effects in other tissues.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

The researchers note that CD8 + T cells could potentially be used as markers for the progression of fatty liver disease, which is expected to become the leading indication for liver transplantation within the next one or two decades.

Lin and Artandi wondered whether they could use telomerase expression as a marker to identify the subset of cells responsible for regenerating the liver during normal turnover.