Sentences with phrase «liver histology»

«In this, we hope to further examine the efficacy of this hormone in improving liver histology based end - points in patients with biopsy - proven NASH with fibrosis.»

Not exact matches

The Animal Core routinely provides liver samples to individual investigators either on ice, fixed in formalin for histology, frozen in optimal cutting temperature (OCT) compound for immunohistochemistry, flash frozen or freeze - clamped in liquid nitrogen for biochemical assays or stored in RNA later.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

«The effects of aqueous extract of Bulbine natalensis Baker stem at 25, 50, and 100 mg / kg of body weight for 14 days on the functional indices of liver and kidney as well as the histology of the rat organs were evaluated.»