Sentences with phrase «livers of animal models»

Not exact matches

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

«We have demonstrated for the first time in an animal model that maternal use of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, resulted in increased fat accumulation and inflammation in the liver of the adult offspring, raising new concerns about the long - term metabolic complications in children born to women who take SSRI antidepressants during pregnancy,» says PhD student Nicole De Long, who presented this research on June 22nd at the joint meeting of the International Society of Endocrinology and The Endocrine Society.

In addition to identifying how the virus causes acute liver injury, the UNC team, along with colleagues at North Carolina State University, established a new animal model of infection with the virus.

In a study published in the June 12 edition of Science, they detail how a new drug repaired damage to the colon, liver and bone marrow in animal models — even going so far as to save the lives of mice who otherwise would have died in a bone marrow transplantation model.

Researchers gave animal models an oral supplement of spermidine and found that they lived longer and were less likely than untreated individuals to have liver fibrosis and cancerous liver tumors, even when predisposed for those conditions.

He notes that, at least in their animal model, liver cell function appeared normal after blocking the function of DLP1.

Using an animal model, they found that TIMP - 1 recruits immune cells by increasing the levels of a specific signaling molecule in the liver.

If we can prevent the formation of metastases in the liver, at least in an animal model, that is a major step towards developing new treatments for cancer patients.»

Through imaging of the liver in animal models, scientists discovered that platelets are constantly interacting with the Kupffer cells by «touching» them to search for captured bacteria.

The animal model which was used to examine the long - term effects of metabolic syndrome * enabled the scientists to elucidate new mechanisms that cause fatty liver disease and also show how it can develop into liver cancer.

If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

Liver Regeneration — Glycyrrhizin, a compound found within licorice, and which we recently featured as a powerful anti-SARS virus agent, has also been found to stimulate the regeneration of liver mass and function in the animal model of hepatecLiver Regeneration — Glycyrrhizin, a compound found within licorice, and which we recently featured as a powerful anti-SARS virus agent, has also been found to stimulate the regeneration of liver mass and function in the animal model of hepatecliver mass and function in the animal model of hepatectomy.

It appears that in the simian model used by us, the liver injury caused by AFB1 is accentuated by simultaneous restriction of dietary protein and in animals on such combined regimen preneoplastic lesions appear around 90 weeks of experiment.

Several studies done on animal models have suggested that the principal compound in cilantro, linalool, has an ability to revamp and boost the antioxidant function of the liver.

Studies in animal models of NAFLD have shown that nicotinamide mononucleotide supplementation corrects biochemical and microscopic liver changes in mice fed a high - fat diet.65, 66

The Whole Prey Model of raw includes whole pieces of muscle meat, bone, liver, and offal; some raw feeders will feed a whole animal, with fur (for fiber) and all.