Genomically encoded analog memory with precise in vivo DNA writing in
living cell populations
We describe a scalable platform that uses genomic DNA for analog, rewritable, and flexible memory distributed across
living cell populations.
In this work, we use the DNA of
living cell populations as genomic «tape recorders» for the analog and distributed recording of long - term event histories.
Not exact matches
Since the
population of
cells down there is small, most people thought they would just barely be able to eke out a
living, that they were organisms with very few capabilities.
From single -
celled organisms to human
populations, viruses affect all
life on earth, often determining what will survive.
If such a
population of
cells existed, women might be able to produce new eggs later in
life.
The use of
cell surface markers to isolate specific
cell populations is one common method for separating
cells; however, isolating
live cells based on their RNA expression is a powerful new way enabling the study of small
cell niches in nongenetically modified animal models and human tissue.
The
population of T
cells that remains are tissue resident memory
cells, which
live long term in skin and, when functioning properly, should be fighting infection.
Now that they have identified the long
lived, skin resident T
cell population that appears to be driving recurrence, the team plans to search for new therapies that can deplete these resident T
cells, potentially driving the disease into long term remission.
Using sensitive
live cell imaging, the team noted that endocytic waves initiated by clathrin emerge in some
cell populations.
Using molecular tools, he and his colleagues conducted a study, published in Science in 2012, which showed that a large
population of fungal
cells — called a mycobiome —
lives in the gut and likely plays a role in IBD.
The adipocyte - enriched
population (gray bars) expressed small amounts of the macrophage markers (a), consistent with residual macrophage contamination seen by immunofluorescent staining of
live cells (b).
Events were gated as follows: singlets (FSC - A by FSC - H),
live cells (SSC - A by Live / Dead), lymphocytes (FSC - A by SSC - A), CD3 + CD4 + (CD3 by CD4), and then events were divided into CXCR4 + and CXCR4 - populations based upon a fluorescence minus one (FMO) cont
live cells (SSC - A by
Live / Dead), lymphocytes (FSC - A by SSC - A), CD3 + CD4 + (CD3 by CD4), and then events were divided into CXCR4 + and CXCR4 - populations based upon a fluorescence minus one (FMO) cont
Live / Dead), lymphocytes (FSC - A by SSC - A), CD3 + CD4 + (CD3 by CD4), and then events were divided into CXCR4 + and CXCR4 -
populations based upon a fluorescence minus one (FMO) control.
The researchers also found that another
population known as progenitor
cells — differentiated daughter
cells of stem
cells — started to behave like stem
cells: They began to
live much longer than their usual lifespan of a few days, and they could also generate mini-intestines when grown outside of the body.
However, when coupled with the observation that induced eyes continued to grow throughout the
life of the animals (Figure 4D and 4H), these results suggest EFTF - induced eyes contain a self - renewing
population of retinal
cells in the retinal stem
cell niche of the CMZ.
PER2: Deletion of the PER2 gene in mice, associated with the mechanisms of circadian rhythm, appears to improve DNA repair in stem
cell populations relevant to the immune system, resulting in a healhier immune
cell population, better immune function in old age, and a modestly extended
life span.
Quick and reliable assessment of chronological
life span in yeast
cell populations by flow cytometry.
They are the only means to target and manipulate specific
cell types (
populations) within neuronal networks in
living animals.
The hallmark of an effective T
cell response is the formation of a stable long -
lived population of
cells that mediate immune memory.
Because humans are born with a stable
population of RPE
cells that stay put throughout
life, the researchers expected that fixing the
cells once would make a lasting impact — and indeed, the vision of patients who got the therapy improved after a single treatment.
Assuming that the findings of the review reflected a causal relation between smoking cessation and risk of all cause mortality, we further investigated the data by constructing
life tables for a hypothetical group of 100 patients aged 65 years with early stage lung cancer to estimate how many deaths would be prevented by smoking cessation within the non-small
cell lung cancer and small
cell lung cancer
populations during five years.
But some things make
life today more insane:
cell phones, traffic, increased
population, fake food, TV, busy schedules.
But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast
population of organisms that
live in your body and outnumber your own
cells ten to one.
Among other projects, according to Pop!Tech, she's designing a cheap wind turbine capable of generating enough electricity to charge a
cell phone or power LED lighting in Guatemala, where 75 percent of the
population lives below the poverty line.