When they injected the soil bacterium Clostridium [ck] novyi into the bloodstream of mice with tumours, it spread throughout the necrotic region, consuming
living tumour cells as well as dead tissue.
This bank of
living tumour cells allowed the team to study not only the genetics of the cells, but also how genetic mutations in the mitochondria — which drive energy production in the cell — caused changes in the cell's metabolism.
This involves crushing
live tumour cells and measuring the metabolites they contain using a mass spectrometer.
Not exact matches
Even soil -
living or flesh - eating bacteria, engineered viruses, weed extracts, microwaves, chemicals from Antarctic sea squirts and the immune
cells of siblings have been recruited to destroy
tumours.
We are investigating how
tumour cells can disseminate from the primary
tumour and remain alive but clinically undetectable for many years, and how they start expanding into
life threatening cancers in some patients.