There was speculation that he suffered from frontotemporal
lobar degeneration, a disease which alters the executive functions of the brain.
58/4: 15 Neuronal aneuploidy and associated apoptosis in familial and sporadic frontotemporal
lobar degeneration indicate that FTLD, like Alzheimer's disease and Niemann - Pick C1, is a cell cycle disorder.
On further examination she was found to have clinical findings consistent with frontotemporal
lobar degeneration of the non-fluent progressive aphasia subtype.
Common pathobiochemical hallmarks of progranulin - associated frontotemporal
lobar degeneration and neuronal ceroid lipofuscinosis.
This case highlights the fact that frontotemporal
lobar degeneration / progressive supranuclear palsy (FTLD / PSP) and other «tauopathies» represent a complex group of neurodegenerative disorders that may masquerade for many years as refractory psychiatric disorders.
Frontotemporal
lobar degeneration (FTD) and amyotrophic lateral sclerosis (ALS): a short tale of two neurodegenerative diseases.
The frontotemporal
lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Regulated intramembrane proteolysis of the frontotemporal
lobar degeneration risk factor, TMEM106B, by signal peptide peptidase - like 2a (SPPL2a).