Sentences with phrase «local cytokine production»

The substantial increases in local cytokine production over time (Figure 2) have been assumed to be primarily a function of their local synthesis at the site by the cells that are migrating to the chamber.22, 58 In our data, correlations between cell numbers and cytokine levels at 22 hours after the social support interaction were r = 0.29 and P <.01 for IL - 6; r = 0.08 and P =.45 for TNF - α; and r = 0.13 for IL - 1β and after the conflict interaction, r = 0.52 and P <.001 for IL - 6 and r = 0.38 and P <.001 for both TNF - α and IL - 1β.

Not exact matches

Severity of AP has been predicted by the magnitude of local and systemic inflammatory cytokine production [33] and several reports have well documented for over activation of leukocytes being the major contributor of inflammation leading to multiple organ dysfunction syndrome [34].

Another is local inflammation which is an increased production of what are called cytokines, like tumour necrosis factor for example.

Consistent with other investigators, 22,58 there were not reliable relationships between the local production of cytokines at inflammatory sites and levels in systemic circulation (data not shown); thus, local production is the primary presumptive pathway.22, 58

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

To separate the effects of the short - term stress of a marital conflict from the long - term strains of marital discord on local and systemic proinflammatory cytokine production as well as wound healing, couples were recruited for two 24 - hour admissions to our General Clinical Research Center (GCRC).

Thus, a series of studies have shown that marital conflict alters physiological functioning, and hostile behavior, particularly during conflict, markedly enhances adverse physiological changes; moreover, women appear to be more adversely affected than men.5 In this study, we extended this line of research to assess how hostile marital behavior modulated an important health outcome, wound healing, as well as local and systemic proinflammatory cytokine production.

Objective To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.

Couples» interpersonal behavior, wound healing, and local and systemic changes in proinflammatory cytokine production were assessed during each research unit admission.

Prior work with the blister - chamber model showed that even modest levels of stress prior to wounding were reflected in lower production of proinflammatory cytokines at the wound site.21 Thus, the fact that the social support interaction always occurred at the first GCRC admission and yet wound healing and local IL - 6, TNF - α, and IL - 1β production were all poorer following conflict suggests that the effects of the disagreement were larger than our data suggest.