Whether and how to
treat localized prostate cancer is thus a difficult decision, and depends largely upon an appraisal of the aggressiveness of the tumor and the likelihood that the cancer will spread to other organs.
The current authors evaluated the effects of ADT on mental and emotional well - being in men diagnosed with
localized prostate cancer using data from the CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) registry, which consists of data from largely community - based practices across the United States.
Failure to control early,
localized prostate cancer results in a poor clinical outcome, according to research published in the International Journal of Radiation Oncology Biology Physics.
In a report published in the New England Journal of Medicine, scientists say that a panel of 20 genes can distinguish the more
common localized prostate cancer that grows slowly and rarely spreads from the more aggressive type that can spread quickly.
In the experiments reported in Nature, the scientists used mass spectrometry, a technique that identifies chemicals based on the size and electrical charge of their components, to compare the levels of 1,126 metabolites in healthy prostate tissue,
clinically localized prostate cancer, and metastatic prostate cancer.
The much - awaited results of a large randomized trial comparing three approaches to
localized prostate cancer were published in The New England Journal of Medicine today.
«Treatment with a shorter course of radiation and higher doses over fewer days may be the preferred approach in appropriately selected patients with
localized prostate cancer, reducing treatment time and cost to the patient, and increasing patient convenience and access to treatment.»
The ASCO report recommends active surveillance for most patients with low - risk,
localized prostate cancer, using regular monitoring with the prostate - specific antigen, or PSA, blood test, prostate biopsy and digital rectal exam.
If a patient is diagnosed with
localized prostate cancer that is aggressive, treatment can be curative.
The research, led by Daniel Krauss, M.D., a radiation oncologist, Beaumont Hospital — Royal Oak, found an association between positive post-radiation therapy biopsy results and subsequent clinical outcomes in men with
localized prostate cancer.
Independent target metabolite analyses revealed significant increases of sarcosine, glycine and choline tissue levels from benign prostate tissue to
localized prostate cancer and subsequently metastatic disease.
Based on these studies, as well as others showing a potential synergistic effect of CTLA - 4 blockade with anti-androgen therapy, Dr. Sharma initiated a pre-surgical clinical trial of anti-CTLA-4 in patients with
localized prostate cancer.
The rate of mutations in these genes was nearly 12 % among these men, compared to about 5 % among men with slower growing,
localized prostate cancer.
Ablatherm - HIFU is generally recommended for patients with
localized prostate cancer (stages T1 - T2) who are not candidates for surgery or who prefer an alternative option, or for patients who failed radiotherapy treatment, Ablatherm - HIFU is approved and commercialized in Europe as a treatment for prostate cancer and is currently under regulatory review in the U.S..
Long - Term Outcomes and Prognosis of Transrectal High - Intensity Focused Ultrasound Therapy for Patients with
Localized Prostate Cancer — Therapy after Recurrence and Predictive Factors