In Panels C and D, the observed activity pattern (blue) was very similar to that observed in the spatial - imagery
localizer scan (i.e., activity in both the parahippocampal gyrus and the supplementary motor area), indicating a «no» response.
the patient responded «no» (also correctly) with activity that matched that observed in the spatial - imagery
localizer scan (Figure 3C).
In all subjects, the pattern produced in response to each question was quantitatively more similar to the pattern observed in
the localizer scan for the imagery task that was associated with the factually correct answer; this answer was verified after the analysis.
the patient responded «yes» (correctly) with activity that matched that observed on the motor - imagery
localizer scan (Figure 3A).
Conversely, the imagery period as compared with the rest period for questions 2 and 3 was associated with extensive activation of the parahippocampal gyrus and, to a lesser extent, the supplementary motor area; these findings closely matched the activation seen in the spatial
localizer scan.
The multiple
localizer scanning sessions of the patient who also underwent communication scanning were averaged with the use of a fixed - effects model.
First, two so - called
localizer scanning sessions were conducted in which the patients were instructed to alternate 30 - second periods of mental imagery with 30 - second periods of rest.
In this patient, the activity observed on the communication scan in response to five of the six questions closely matched that observed on one of
the localizer scans (Figure 2A and 2C and Figure 3A and 3C).
First, activity in the two regions of interest (the supplementary motor area and the parahippocampal gyrus) identified during
the localizer scanning was quantitatively characterized (with the use of the average generalized linear model estimate for each region of interest).
The patterns of activation in the regions of interest (the supplementary motor area and the parahippocampal gyrus) in the motor and spatial
localizer scans and the communication scans obtained from one patient and one healthy control subject are shown.
For all 48 questions in the communication task, the correct answer was determined with 100 % accuracy by comparing the activations shown on the communication scans with the activations shown on two
localizer scans.
Communication scanning was identical to
localizer scanning with the exception that the same neutral word «answer» was used to cue each response to a question (with «relax» used as the cue for rest periods).