Many HARs are
located near genes that control fundamental developmental processes, 9 so their altered regulatory function could have profound effects on human biology.
Of particular interest was that four of the 10 sites most strongly linked to the AOSI scores were
located near genes linked to Prader - Willi syndrome, a genetic disorder that shares some behavioral symptoms with autism.
Although the teams took very different approaches to solve the mystery of how those limbs vanished, both came up with similar results: Mutations in DNA
located near a gene key to limb formation keep that gene from ever turning on, they report today.
Not exact matches
In addition, Kuchina and colleagues used biotechnology to engineer mutant forms of B. subtilis in which the two critical
genes were
located near one another.
They knew that
genes that evolve within a prokaryote's own genome are often
located near similar
genes and have similar functions in existing
genes.
So his team sifted through genetic information from 45,000 microbes, flagging groups of
genes with unknown functions that were
located near known defense - related
genes.
Based on the similarity in the DNA sequences
located near the caspase - 12
gene, Tyler - Smith and his colleagues estimate that the nonsense mutation occurred about 500,000 years ago in Africa.
Some of these SNPs had previously been associated with different diseases and are
located near «imprinted»
genes —
genes in which only the maternally or paternally inherited copy is «switched - on» to encode a protein.
Distribution of individual CpG sites
located in or
near genes that exhibit differential expression in T2D discordant twins, and that show an inverse (I) or positive (J) relationship between DNA methylation and mRNA expression in the discordant twins in relation to CpG island regions.
All seven were
located in or
near complement
genes (that's «complement» as in the innate immune system complex), which had been implicated in AMD by sequencing studies over the past couple of years.