Not exact matches
In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mic
In their study, the researchers showed that already at the age of six weeks
in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mic
in the mice with a rapid weight gain, the DPP4
gene was less methylated at four
specific loci, i.e. epigenetically altered, compared to the other mice.
The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait
loci (eQTLs), which link polymorphisms
in single
genes to quantifiable changes
in gene expression associated with
specific diseases.
To demonstrate the critical role for ecRNA - directed methylation, first author Katherine Savell, a graduate student
in the Day lab, blocked one
specific ecRNA for the Fos
gene locus in the hippocampus of the rat brain.
Despite evidence for divergence at several
loci, certain 1a characteristics were preserved including the length of the alternative reading frame / F protein (ARF / F)
gene, and a subtype 1a -
specific phosphorylation site
in NS5A (S349).
«It's hard to fit every single
locus in the genome into one
specific model of
gene regulation.
Bivalent marking of
loci encoding lineage
specific transcription factors
in ES cells is thought to prepare these
genes for rapid activation of transcription once the pluripotency network is extinguished [4].
It is important to distinguish lineage
specific gene expression shown here, which occurs at a high level and with a degree of specificity
in the different population compartments, to the low level of genome wide transcription observed
in ES cells by others [22], or with transcript initiation at many
loci noted previously
in ES cells [23].
Saturday, Oct. 21, 11:20 - 11:40 a.m., South Hall B, South Building Featured Plenary Abstract: Massively parallel reporter assays combined with cell - type
specific expression quantitative trait
loci profiling identified a functional melanoma risk variant
in HIV - 1 inhibitor
gene, MX2 J. Choi, National Cancer Institute, et al
With the premise that accumulation of putative resistance - conferring SNPs, potentially
in combination with
specific resistance
genes, precedes full resistance, we retrogressively surveyed the hotspot
loci and quantified the number of SNPs and / or
genes, which if accumulated would confer full resistance to an otherwise susceptible strain.