Sentences with phrase «locomotor activity»

Notably, the mutant mice also showed periodic changes in locomotor activity in their home cages with an approximate cycle length of 10 - 20 days.

Sensitization of Locomotor Activity in the mouse as a Potential Indicator of Abuse Liability B.J. CALDARONE, C.M. RUIZ, M.L. MANZANO, A.C. FEDOLAK, J. ZHOU, B. OLIVIER... Abstracts / Posters

This is the first evidence that a mutation in a non-coding region of the genome is able to influence the period of circadian locomotor activity.

The researchers explain this: with long - lasting high exposure to triglycerides, mice always display lower locomotor activity.

To better test the effects on locomotor activity in response to certain compounds, zebrafish larvae can be loaded into multi-well plates.

In this one experiment, chronic supplementation of L - tyrosine decreased locomotor activity of the Roborovskii hamsters in the home cage (Hodgkins et al. 2012).

Schirmer and her team found other major differences between the fish tests and the patterns observed in mammals: while cocaine has a stimulatory action and causes hyperactivity in mammals, it suppresses locomotor activity in zebrafish.

The researchers were able to show that activation of mTORC1 in the liver of mice reduces not only hepatic lipid metabolism but also locomotor activity and body temperature.

Based on the gene expression data, they constructed models for retrospectively predicting locomotor activity of individual mice.

Recently, studies have revealed differing neurological and locomotor activities when comparing IL - 15Rα — KO, IL - 15 — KO, and IL - 2Rβ — KO mice (14, 15).

Researchers also found that levels of cAMP and pCREB, possible upstream regulators of some circadian genes, were correlated with locomotor activity.

«Gene expression patterns in the hippocampus may retain information about past locomotor activity.»

«It is also of interest whether certain molecular signatures in the samples, such as blood and cerebrospinal fluid, obtained from living animals can predict past and future locomotor activity.

At first, researchers longitudinally monitored locomotor activity of 37 αCaMKII mutant mice by calculating the distance traveled in their cage for over 2 months.

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

These results support the idea that hippocampal pCREB levels may modulate locomotor activity.

Knockdown of both dec1 and per2 genes resulted in a noticeably disrupted circadian locomotor activity pattern.

Finally, there are modest effects on daily patterns of behavior; while overexpression of Bmal1 in the skeletal muscle does not affect the timing or intensity of daily rhythms of wheel running, overexpression of Bmal1 does lead to an increase in general locomotor activity, particularly at the light - dark transitions and middle of each photoperiod.

Research synopsis: Dr. Brager's research interest focuses on how the structure and function of skeletal muscle influences locomotor activity and sleep.

In this study (Nucleic Acids Research, 2014), genes dec1 and per2 were tested further and found to be essential for the light entrainment of the rhythmic locomotor activity of larvae.

Transmembrane and ubiquitin - like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.

Serotonin N - acetyltransferase (Aanat) as a candidate gene for mouse baseline locomotor activity measured in the home cage Lin Liu, King's College London, UK

As expected, our DA deficient flies have no detectable DTH or DA in the brain, and show reduced locomotor activity.

In this study, the effect of lesion of the cholinergic pedunculo - pontine cell bodies (PPN) by the excitotoxin quisqualic acid was investigated on spontaneous locomotor activity and learning in rats.

PPN lesion had no effect on initial nor on nocturnal locomotor activity in a circular corridor.

During this deprivation period, the «mice showed decreased voluntary locomotor activity, diminished physical strength, and increased preference for a highly palatable sucrose reward.»

Neonatal Isolation Stress Inhibits Pre-Weaning Weight Gain and Mild - Stressor Induced Locomotor Activity in Early Adolescent Male and Female Rats

The researchers found that gene expression patterns in the hippocampus accurately predicted whether the mice were in a state of high or low locomotor activity.

To entrain rhythms of locomotor activity, 5dpf larvae were exposed to 3 hours of light, after which they were monitored under dim light conditions.

Other contributors to the study, «The novel recreational drug 3,4 - methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self - administration and locomotor activity in rats,» in Neuropharmacology (Volume 71), were P.K. Huang and K.M. Creehan of TSRI.

A reduction in locomotor activity was observed only in ants that ingested nectar, making them stay around the larvae longer.

Thus, the researchers examined the list of genes used for the successful prediction of locomotor activity.

Furthermore, researchers found that drugs that are used to treat bipolar disorder controlled the locomotor activity and changed hippocampal pCREB expression in the mutant mice.

In the current study, prediction analysis of gene expression data was implemented in order to identify the genes that are most useful to determine the state of cyclic changes in locomotor activity.

«We saw changes in the brain chemistry in ways that are known to have an impact on the reward pathway, locomotor activity, and other behaviors, as well as effects on body weight,» Thanos says.

The changes in locomotor activity are associated with fluctuations of anxiety - like and depression - like behaviors, suggesting that the mutant mice may serve as an animal model showing infradian oscillations of mood substantially similar to those found in patients with bipolar disorder.

With the first spontaneous movements taking place as early as 17 hours post-fertilization and swimming behavior occuring after 27 hours, zebrafish embryos prove to be a good model for the study of development of locomotor activity.

In the future, Dr. Brager plans to examine whether there are any brain correlates to how the skeletal muscle regulates daily rhythms of locomotor activity and sleep.

Effects on learning and memory, social interaction, anxiety - related behaviors, locomotor activity, and pain sensitivity have been reported (6, 24).

Importantly, at both time points examined, there were no differences in locomotor activity and / or pain sensitivity between rat groups (Additional file6: Figure S5), suggesting that the reduced fear conditioning responses (freezing behavior) in transgenic rats were not influenced by any differences in sensitivity to pain or by increased locomotion.

Additional file 6: Figure S5: Analysis of locomotor activity and pain sensitivity in McGill transgenic rats.

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

The improved metabolism of PrcpAgRPKO mice was associated with reduced food intake and increased energy expenditure, locomotor activity, and hypothalamic α - MSH levels.

In comparison to rats fed a standard diet, those who consumed hydrogenated vegetable fat displayed a reduction in exploratory and locomotor activities.

In this manuscript, Murphy et al. develop a novel assay combining the CAFE assay with video measurements of locomotor activity, in order to simultaneously assess feeding and sleep in Drosophila.

In a 2005 study, scientists gave female rats high and low doses of caffeine and observed that `' caffeine selectively increased visits to the male when physical contact was possible,» a result they say suggests that `' the effects of caffeine on female mating behavior may reflect an increase in both sexual motivation and locomotor activity.»

For example, Roborovskii hamsters are characterized by low levels of dopamine in the brain and high levels of locomotor activity (an indication of hyperactivity disorder) compared to other species of hamsters.