Sentences with word «locoregional»

[57] The postoperative use of radiotherapy for anorectal melanoma following wide local excision has been reported to be associated with high rates of locoregional control (74 % to 82 %) at 5 years, with nearly all patients avoiding the need for abdominoperineal resection and permanent colostomy.

The rate of locoregional recurrence (in the breast and surrounding area) was not significantly different between groups: 1.3 percent for women who had lipofilling versus 2.4 percent in those who did not.

The sole exception was women receiving hormone therapy, for whom lipofilling was associated with a small but significant increase in locoregional recurrence risk: 1.4 versus 0.5 percent.

By the final analysis of this study, completed in 2012, ORRs had risen to 58 % and 40 % in target and bystander lesions, respectively, with locoregional disease control at 80 % and 60 % for the target and bystander lesion groups, respectively.

Effective locoregional control can be obtained through complete surgical resection, although wide negative margins may be difficult to achieve.

Unfortunately, wide negative margins are often difficult to achieve in mucosal melanoma due to anatomic constraints, disease multifocality, and / or a lentiginous growth pattern, and most mucosal melanomas recur regardless of initial locoregional management.

Moreover, primary tumor locations should be carefully considered when deciding treatment intensity in metastatic and locoregional settings, and should represent an important stratification factor for future adjuvant studies,» the article concludes.

Despite aggressive locoregional management, recurrent disease is common and treatment in this setting remains challenging.

Patients with ER - negative, but not ER - positive, isolated locoregional recurrence after unilateral breast cancer derive significant benefit from chemotherapy.

For melanomas that arise in the sinonasal mucosa, Moreno et al found that conventionally fractionated radiation to a dose of at least 54 Gy achieved superior locoregional control (45.4 %) compared with hypofractionated radiation (0 %).

In these patients, clinical results with systemic therapy have been less than optimal, and locoregional therapeutic options, such as limb perfusion and intralesional treatments, have thus been explored.

Learn the basics of locoregional analgesia and postoperative options for treating pain in the hospital and at home.

Effective locoregional control can be obtained through complete surgical resection.

The results show no increase in the risk of locoregional or systemic recurrence in women with breast cancer who undergo breast reconstruction with lipofilling.

The ORR for bystander lesions was 37 %, and the locoregional control rate was 55 %.

Furthermore, while it is true that metastatic melanoma is a systemic disease — and also that mortality is not caused by dermal or subcutaneous lesions but rather by metastases to the liver, brain, lung, and other sites — locoregional disease is often disfiguring and painful, and locoregional therapy may provide clinical benefit.

Preliminary analyses of the results of the first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as treatment for patients who can not tolerate systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.