Sentences with phrase «locus identified»
This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.
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Another one of the loci identified, SNCA, is also associated with Parkinson's, but differently — the researchers found that a different part of the gene is linked to DLB.
CRGGH continues to use genomic data generated in African populations to refine and fine - map loci identified in European and Asian populations for multiple traits including glucose, uric acid, bilirubin, CRP and serum lipids.
Twelve type 2 diabetes susceptibility loci identified through large - scale association analysis
These loci identified through...
In 2004, in collaboration with Dr. Joan Bailey - Wilson and others, he identified a region of chromosome 6q23 - 25 that harbors a locus greatly increasing lung cancer risk, and showed in 2010 that this locus identifies individuals exquisitely sensitive to tobacco smoke.
Not exact matches
He has identified all the crucial loci, save one: the rise of postmodernism, as illustrated by Jean - François Lyotard's The Postmodern Condition: A Report on Knowledge.
We are also mistaken in identifying the boundaries of the attended event with the boundaries of its apparent locus (in the focal region).
5Actually, it is the «presented locus» that is defined by perception in the mode of presentational immediacy (PR 195f, 492), and Whitehead notes in several places that in keeping with the results of physical science the presented duration and the presented locus are not to be identified (PR 192 - 96, 492f).
Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.
Furthermore they identified genetic loci contributing to skin microbiota variability, susceptibility to skin inflammation and their overlap.
The so - called SERPINB gene cluster on chromosome 18 was identified as a specific genetic risk locus for food allergies.
The new locus they have identified is near a cluster of genes which code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood cells.
The investigators confirmed the activity of genes at the newly identified loci by probing discarded corneal tissue from deceased individuals with and without Fuchs.
«We identified one genome - wide significant locus for anorexia nervosa on chromosome 12, in a region previously shown to be associated with type 1 diabetes and autoimmune disorders,» said lead investigator, Cynthia Bulik, PhD, FAED, founding director of the UNC Center of Excellence for Eating Disorders and a professor at Karolinska Institutet in Stockholm, Sweden.
From the genome wide scan, a set of gene loci correspond to thermostatic regulation has been identified.
«For anorexia nervosa, researchers implicate genetic locus on chromosome 12: Powerful genomic study of anorexia nervosa conducted to date to identify the common roots anorexia shares with psychiatric, metabolic traits.»
Substantially, a nearly complete catalogue of the genetic variants has been compiled, which allowed the scientist to identify a genome - wide set of loci for local adaptation in Chinese pigs.
A landmark study led by UNC School of Medicine researchers has identified the first genetic locus for anorexia nervosa and has revealed that there may also be metabolic underpinnings to this potentially deadly illness.
In 2010, researchers from the Cummings School of Veterinary Medicine, the University of Massachusetts Medical School and the Broad Institute at the Massachusetts Institute of Technology identified a genetic locus on canine chromosome 7 that coincides with an increased risk of OCD.
Among these conserved loci, 207 had not previously been identified as canine microRNAs.
«If we can identify similar genetic loci in people, and if we could find biomarkers for these gene - environment interactions, then perhaps we could develop a simple blood test that identifies people who are at high risk of cancer from low - dose radiation,» says Mao.
To assist with this problem, the researchers identified the genome region involved with self - compatibility, called the S - locus.
The short size of the locus was ideal for 454 sequencing, and because single - molecule reads are generated, the authors were able to identify haplotypes of somatic hypermutations carried by individual leukemic cells.
Theoretically speaking, about 10 - 12 carefully chosen STR loci are sufficient to identify an individual.
our stroke research, we will soon be able to find a gene within the type 2 diabetes locus we have identified and use this gene to identify powerful new drug targets.»
Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.
In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.
This is the case at the level of loci (e.g. identifying causal variants underlying genome - wide associations), genes (e.g. understanding not only that mutations in gene X underlie a given phenotype, but also the how and why of it), and variants (e.g. variants of uncertain significance).
Genome - wide association study identifies shared risk loci common to two malignancies in golden retrievers.
The genetic variant identified to be associated with the brain aging rate at the TMEM106B locus is also extremely frequent: 80 percent of the population carries at least one copy of the allele associated with increased aging rate in their genome, Rhinn said.
Continued research will focus on identifying the mutated gene's location within the locus.
By doing genome - wide association, we identified loci predisposing to hemangiosarcoma and B - cell lymphoma.
Notably, the West African cohort has been useful for refining the association signals found in European and Asian ancestry populations; it has provided some of the earliest evidence for how relatively diverse populations might facilitate fine - mapping of loci originally identified in more homogeneous populations characterized by larger regions of strong linkage disequilibrium.
We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
GWAS loci in 5 genes reaching genome - wide significance for BP were identified.
As a result of their equally balanced admixed ancestry, the Malagasy may represent an ideal population in which to identify loci underlying complex traits of both anthropological and medical interest.
In collaboration with deCODE Genetics, susceptibility loci for T2D were identified in three genes (TCF7L2, CDKAL1, and TCF2 [HNF1β]-RRB-.
We focused on a conservative set of 125 loci that were identified by at least two of the above methods so as to limit method - specific bias and narrow the list of candidates.
A large genome - wide association study has identified eight new loci that confer susceptibility to osteoarthritis, researchers reported...
We have identified 145 metabolic loci connecting more than 400 different metabolites, defining the in vivo blueprint of human metabolism.
Genome - wide association study identifies two novel Loci with sex - specific effects for type 2 diabetes mellitus and glycemic traits in a korean population
An Italian association study and meta - analysis with previous GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibility loci for endometriosis.
To reconstruct modern human evolutionary history and identify loci that have shaped hunter - gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter - gatherer populations at > 60 × coverage: Pygmies from Cameroon and Khoesan - speaking Hadza and Sandawe from Tanzania.
Results from recent GWAS studies have identified over 50 distinct SNP loci associated with either pigmentation phenotypes or susceptibility to melanoma.
(iii) Our work recently identified the first endogenous inhibitor of the leukocyte adhesion cascade, the endothelial - derived developmental endothelial locus - 1 (Del - 1) that antagonizes integrin - dependent leukocyte adhesion to the endothelium and IL -17-dependent inflammation.
Genome - wide association and large - scale follow up identifies 16 new loci influencing lung function.
Meta - analysis identifies 13 new loci associated with waist — hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution.
Recent genetic association studies identified variants in a locus on chromosome 15 (specifically, in the adjacent genes HERC2 and OCA2) that are major determinants of eye color, but the trait is influenced by interaction among at least ten different genes.