C. On chromosome 19, one of the few megabase regions showing decreased methylation in CPA compared to controls contains one of the two human micro-RNA clusters (scale
log2 fold differences top and bottom panels: − 0.2 to 0.2).
Shaded in blue is a 500 Kb region containing protocadherins family A and B whose promoters are consistently less methylated in CPA than in controls (scale
log2 fold differences: − 0.2 to 0.2).
The olfactory receptor clusters located on chromosome 1 and chromosome 11 are less methylated in CPA compared to controls (scale
log2 fold differences: − 0.2 to 0.2).
Not exact matches
Differentially methylated regions from the microarray analysis with varying p values (between 0.0001 and 0.03 with FDR < 0.2) and
fold differences (
Log2 CPA / Controls between 1.1 and 0.5) at the probe level were selected for validation.