Sentences with phrase «long gene expression»

It's not clear how long the gene expression changes may last.

The researchers also found that the degree of increased long gene expression correlates with disease severity: mice with more severe Rett - like symptoms displayed more overexpression.

They next analyzed long gene expression in mice of different ages.

Greenberg's lab also found that the disruption of long gene expression appears to be a distinctive signature of Rett Syndrome and related disorders.

Not exact matches

The good news is that little tweaks in your diet, like adding foods that are high in long - chain omega - 3 fats, can change the expression of your genes.

Procured from algae, algal oil is source of DHA, an important long - chain omega - 3 that supports brain development, immune balance, and healthy gene expression.

Secretory antibodies in breast milk promote long - term intestinal homeostasis by regulating the gut microbiota and host gene expression

Molecular studies of gene expression during long - lasting synaptic plasticity related to memory storage initially focused on the identification of positive regulators.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

«But the question had remained: How long can you get the gene expression to last?»

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

But those from the hotter pool survived for longer and had higher expression of 60 genes, including well - known thermal - tolerance genes such as those that make heat - shock proteins and antioxidant enzymes.

L2 plays an important role in cells by activating mRNA decay, a system cells use to turn off gene expression when the proteins encoded by the mRNAs are no longer needed.

It had long been assumed that specific proteins bind to a metabolite and trigger expression or repression of genes.

«The orchestration of gene expression no longer seemed coordinated as the organism aged and the results were confusing because genes related to the same function were going up and down at the same time,» says Petrascheck.

«Using a technique developed by our collaborators at the University of Iowa, we were able to get long - term expression of these human gene variants in the fluid that bathes the entire brain,» says Bradley Hyman, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH - MIND), senior author of the report in the Nov. 20 Science Translational Medicine.

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

The study, led by Michael Greenberg, Ph.D., Chairman of the Department of Neurobiology at Harvard University, shows that MECP2 dampens the expression of long genes.

Enzymes called topoisomerases are crucial for the expression of extremely long genes, including many that have been linked to autism

The researchers in the Greenberg lab found that across all analyzed datasets, and in studies of different mouse brain regions, in the absence of MECP2 the expression of long genes is increased.

The researchers found that the expression of a clock gene named frequency (frq) is controlled by a long non-coding RNA named qrf (frq backwards) − an RNA molecule that is complementary, or antisense, to frq.

«Long - held assumption of gene expression in embryonic stem cells challenged.»

The researchers believe that studying the expression of vitamin D dependent genes in tissues is a novel way to identify individuals who might benefit from long - term vitamin D supplementation.

The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles.

The current U.K. trial is again using fats, or lipids, but the DNA includes a segment called a promoter that should make gene expression last longer, says Eric Alton of Imperial College London, who heads the UK Cystic Fibrosis Gene Therapy Consortgene expression last longer, says Eric Alton of Imperial College London, who heads the UK Cystic Fibrosis Gene Therapy ConsortGene Therapy Consortium.

Changes in DNA methylation in brain cells has been an extremely active research area since these epigenetic changes were shown to alter the expression of genes needed to form and maintain long - term memories.

Although we have long known that this signal strongly inhibits protein synthesis in general, during hemoglobin gene expression it first plays its indispensable, positive role before being turned off promptly to allow for massive hemoglobin formation needed for breathing,» said Prof. Raymond Kaempfer, the Dr. Philip M. Marcus Professor of Molecular Biology and Cancer Research at the Hebrew University of Jerusalem.

They remained activated long after the gene expression had turned off or gone down in the control animals, thus confirming the earlier observation that the virus causes the immune system to overreact.

The researchers discovered that DNA methylation — a fundamental, life - long process in which a methyl group is added or removed from the cytosine molecule in DNA to promote or suppress gene activity and expression — does in fact vary between FLS from the knees and hips of RA patients.

In the long term, genomic and quantitative spatial gene expression measurements, captured and analysed by methods such as SpatialDE, may form the basis of histology and pathology in the clinic.

A statistical analysis of gene expression allowed the scientists to reject a long - standing hypothesis, namely that histone 1 is a global repressor of expression.

A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of chondrocyte - specific genes and differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.

Long - lasting changes in brain connectivity require new gene expression, and Dr. Martin has discovered a role for specific signaling molecules that travel from stimulated synapses to the nucleus to change the transcription of DNA to RNA.

A long - term goal of our research is to understand how neuronal activity elicits changes in gene expression that are important for learning and memory.

«We were surprised to see that expression of the gene TSLP — which encodes a cytokine long known to be involved in epithelial - induced inflammation — was exclusive to a particular subset of tuft cells,» Haber noted.

Combination of methamphetamine and HIV - 1 gp120 causes distinct long - term alterations of behavior, gene expression, and injury in the central nervous system.

Long - term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques.

As long as the memory element remains intact, either of the two bacteriophage factors that control its function also inhibits the expression of a toxin gene encoded by the Essentializer.

This figure depicts how the expression of the longer transcript in this gene becomes less dominant as PMI increases, and, as a consequence, the abundance of the different isoforms tends to converge

Scientists have long theorized that the way DNA is packaged affects gene expression.

She will determine which cells harbor the most latent and productive HIV and examine the cells» total gene expression to determine how the gut microenvironment contributes to their long - term survival.

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression.

Such long - term expression is important for gene therapy studies in humans.

AAV gene therapy vectors are emerging as the gene transfer vehicle with high potential for use in the CNS as they transduce post mitotic cells that mediate the sustained, long term gene expression required in chronic progressive diseases.

In a developing embryo, for example, a researcher could determine whether or not newly synthesized or long - lived transcription factors control gross changes in gene expression as new body sections are formed.

The Genomics Core at the Buck Institute has had a long standing tradition of providing access to a suite of technologies for interrogating fundamental processes of aging relating to gene expression.

If the cells had evolved under extreme conditions that were more likely to break DNA, «they would have evolved different mechanisms to deal with that, and the efficiency of gene expression would no longer be the first concern.»