Sentences with phrase «long noncoding»
Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.
https://wistar.org/
CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers...
Whitehead Institute researchers report that 10 long noncoding RNAs (lncRNAs) play a vital role in the regulation of white fat cells.
As a result, reference gene collections remain incomplete - many gene models are fragmentary, and thousands more remain uncataloged, particularly for long noncoding RNAs (lncRNAs).
Research Paper Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1 / NF - κB pathway in hepatocellular carcinoma Hui Wang, Linhui Liang, Qiongzhu Dong, Lin Huan, Jia He, Botai Li, Chen Yang, Haojie Jin, Lin Wei, Chengtao Yu, Fangyu Zhao, Jinjun Li, Ming Yao, Wenxin Qin, Lunxiu Qin, Xianghuo He Theranostics 2018; 8 (10): 2814 - 2829.
Long noncoding RNA - mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.
The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes.
Combined RNAi and localization for functionally dissecting long noncoding RNAs.
Long noncoding RNA (lncRNA), which contains more than 200 nucleotides, is thought to play a role in autoimmune diseases and cancers by interacting with other RNA, DNA, and proteins.
The researchers believe that they have identified a group of RNA molecules — known as long noncoding RNAs (lncRNAs)-- that hold the potential for serving as better prognostic markers for prostate cancer.
Other researchers have found that more than 30 percent of long noncoding RNAs — which carry out several different jobs in the cell, most still unknown — are repurposed transposable elements (SN: 12/17/11, p. 22).
That DNA includes slightly less than 21,000 protein - coding genes (some researchers once estimated we had more than 100,000 such genes); «genes» for 8800 small RNA molecules and 9600 long noncoding RNA molecules, each of which is at least 200 bases long; and 11,224 stretches of DNA that are classified as pseudogenes, «dead» genes now known to really be active in some cell types or individuals.
«No longer junk: Role of long noncoding RNAs in autism risk.»
She has described the impact that different estrogen receptors have on breast, pancreatic, and colorectal cancer, including transcriptomic effects involving long noncoding RNAs and microRNAs.
Long noncoding RNA (lncRNA), which contains more than 200 nucleotides, are thought to play a role in autoimmune diseases and cancers by interacting with other RNA, DNA, and proteins.
The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.
Not exact matches
To their surprise and dismay, the genome turned out to contain long stretches of noncoding and repetitive DNA, which made it difficult to piece together the short reads produced by the sequencing machine.
The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR - 143.
Recent studies have revealed that a large part of the genome is copied into lincRNAs (long intergenic noncoding RNAs), of which Gas5 is an example.
A team of scientists from Whitehead Institute and other institutions has shown for the first time how two long intergenic noncoding RNAs (ncRNAs) in brewer's yeast (Saccharomyces cerevisiae) contribute to a location - dependent switch for the yeast FLO11 gene to toggle between active and inactive states.