«
The loss of photoreceptor cells affects virtually all of us.»
Not exact matches
«In the best - case scenario, we thought we could hopefully prevent the
loss of vision in these patients,» he says, because RPE
cells are known to help maintain existing
photoreceptors, in part by digesting the cellular debris that they shed.
«The goal is to halt the rate
of photoreceptor loss,» says Robert Lanza, chief scientist at Advanced
Cell Technology (ACT)
of Worcester, Massachusetts, the company that has been developing the treatment since first turning hESCs into RPEs in 2004.
After initiating
photoreceptor loss in the fish retinas, the researchers monitored the immune system's response by tracking the activity
of three types
of fluorescently labeled immune
cells in and around the eye: neutrophils, microglia and peripheral macrophages.
Most causes
of untreatable blindness occur due to
loss of the millions
of light sensitive
photoreceptor cells that line the retina, similar to the pixels in a digital camera.
Functional damage to these
photoreceptors, or pathological
loss of the
cells that bear them, results in inability to register light impinging on the retina — and is responsible for various types
of visual impairment and certain forms
of congenital blindness.
«This study for the first time shows increased expression
of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation
of myeloid
cells in the outer retina,
loss of photoreceptors, and functional impairment
of the retina in preclinical models
of retina stress,» the authors note.
AMD, a major cause
of irreversible vision
loss in the elderly, results from death
of cells critical for vision: RPE and
photoreceptor cells.
0 Research ArticleRETINAL DISEASES Human ESC — derived retinal epithelial
cell sheets potentiate rescue
of photoreceptor cell loss in rats with retinal degeneration Karim Ben M'Barek 1,2,3, Walter Habeler1, 2,3, Alexandra Plancheron1, 2,3,
In the absence
of myosin VI, the amplitudes
of the a - and b - waves
of the electroretinogram were reduced, although there was not
photoreceptor cell loss and retinal anatomy appeared normal.
One can imagine that
loss of function
of any
of the gene products along this complex pathway could lead to severe consequences for the survival
of the
photoreceptor (PR)
cells in the eye.
In order to study rescue effects following surgery, donor
cells were introduced at P21, an age preceding major onset
of photoreceptor loss.
These retinal
cells are the type that are killed off in macular degeneration, eventually leading to the death
of photoreceptors, and the gradual
loss of central vision.