Not exact matches
«It's seen as a
memory condition but the first thing to go is
loss of spatial orientation.»
Pathological hallmarks
of AD, including plaques and
loss of synaptic markers, are readily apparent at nine months
of age in huAPP / PS1 mice along with clear deficits in
spatial memory when compared to wild type controls [7, 10, 11, 31].
We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model
of the OPHN1
loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition
memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and
spatial memories are partially or not rescued by the treatment.
Research at the University
of New South Wales suggests that high - sugar diets can lead to
memory loss — in fact rats fed a high sugar diet suffered deterioration in
memory and
spatial recognition in less than one week.
Yabut defined «peridementia» as the period in which the subject starts to have a mild version
of the
loss of intellectual capacity that is associated with dementia — i.e., impairment
of attention, orientation,
memory, judgment, language, motor and
spatial skills, and function.