HBS thus crystallizes at
low oxygen tension, causing the formation of inflexible, sickle shaped erythrocytes that block capillary beds and damage internal organs.
Thus, Rho - kinase inhibition at
low oxygen tension can be regarded as a potential way to enhance extracellular matrix production and maintain a chondrocyte phenotype in cell - based tissue engineering applications.
Similarly, certain mtDNA variants are enriched in Tibetan populations, suggesting that mtDNA variation may permit adaptation to
the low oxygen tension at high altitude.