Sentences with phrase «lower allele frequencies»

Some of the earliest studies of cancer genomes in AML noted that, within a single patient, there were subsets of mutations present at lower allele frequencies, suggesting that they're not present in all cells.

Not exact matches

Instead, spontaneously transformed cells arose from the heterozygotes at a low frequency, and the majority of these cells had amplified the mutant allele.

However, most point mutations occur at low frequency, and the function of these alleles remains undefined.

In unadjusted chi2 analyses, the frequency of the minor Ser482 allele was significantly lower in cases than in controls (29.1 vs. 40.0 %; P = 0.01).

We tested the hypothesis that the frequency of the minor Ser482 allele at the PPARGC1A locus is lower in World - class Spanish male endurance athletes (cases)[n = 104; mean (SD) age: 26.8 (3.8) yr] than in unfit United Kingdom (UK) Caucasian male controls [n = 100; mean (SD) age: 49.3 (8.1) yr].

We performed two statistical analyses to support the genetic evidence that indels at this locus, including those observed at low frequency in cfDNA, were likely to represent bona fide reversion alleles.

Yet each one tells a different story: (a), how novel - to - dbSNP variants were rare; (b), how nonsynonymous variant frequencies are shifted to lower values relative to those of synonymous variants, (c), how this shift in allele frequencies is more pronounced for damaging nsSNPs, consistent with natural selection, and (d), how the sizes of observed indels are enriched for non-frameshift events divisible by 3.

The differences between the samples are highest in low - frequency alleles and decrease with increasing allele frequency.

Please note... there is no estimate of the frequency of the false allele at this time, although it is much lower with the recently improved tests.

Nations with a higher frequency of S allele carriers showed a lower prevalence of anxiety (r (12) = − 0.55, p < 0.03) and mood disorders (r (12) = − 0.52, p < 0.05).