Sentences with phrase «lower duration risk»

Finally, compared with high - yield corporate bonds, senior loans offer lower duration risk, given the floating - rate nature.

Not exact matches

Interest rates on 15 - year mortgage terms are typically lower than those on longer - term loans because the shorter duration of the loan makes it less of a risk to the lender.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Interest rate risk Although high yield bonds have relatively low levels of interest rate risk for a given duration or maturity compared to other bond types, this risk can nevertheless be a factor.

«While shortening the duration of a TIPS exposure results in a lower yield, the chart below shows it still provides an attractive breakeven ratio, or yield received for the amount of risk that an investor takes.

While shortening duration can help mitigate interest rate risk, another approach to consider is one that balances exposure to the very front end of the curve with exposure to intermediate maturities for additional yield potential and lower volatility, given that rates are likely to rise slowly and stay historically low for the foreseeable future.

Lower duration TIPS funds» headline yield level may be lower, but their portfolio impact may be more beneficial than broad - based TIPS because they require less duration (risk) to earn that yield,» added MLower duration TIPS funds» headline yield level may be lower, but their portfolio impact may be more beneficial than broad - based TIPS because they require less duration (risk) to earn that yield,» added Mlower, but their portfolio impact may be more beneficial than broad - based TIPS because they require less duration (risk) to earn that yield,» added Mazza.

While all four countries have different durations between 5.24 and 6.47, the U.S. has the shortest duration of them all, with the lowest risk profile and the highest yield.

These flows were directed mainly into lower risk exposures such as shorter duration bond ETFs and cash equivalent funds.

We are watching all of this play out real - time as fixed - income fund flows are broadly shunning sectors with embedded credit and / or duration risks, in favor of freshly attractive, and lower risk, high - carry assets.

Taking the present - day levels of contaminants in Norwegian breastmilk and the long duration of breastfeeding (12 months) in Norway into account, the Norwegian Scientific Committee for Food Safety concludes that contaminants poses a low risk to Norwegian infants, and that the benefits of breastmilk to Norwegian infants clearly outweigh the risk presented by contaminants.

The study showed that breastfeeding is associated with about a 10 percent lower risk of several major cardiovascular diseases in later life among Chinese women, and breastfeeding duration seemed to play a role.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

Duration of breastfeeding was not related to the risk of insecure - avoidant or insecure - resistant versus secure attachment classification, but longer duration of breastfeeding predicted a lower risk of disorganized versus secure attachment classification (n = 151; odds ratio [OR] = 0.81, 95 % CI 0.66 to 0.99, Duration of breastfeeding was not related to the risk of insecure - avoidant or insecure - resistant versus secure attachment classification, but longer duration of breastfeeding predicted a lower risk of disorganized versus secure attachment classification (n = 151; odds ratio [OR] = 0.81, 95 % CI 0.66 to 0.99, duration of breastfeeding predicted a lower risk of disorganized versus secure attachment classification (n = 151; odds ratio [OR] = 0.81, 95 % CI 0.66 to 0.99, p =.04).

These findings agree with the results of a British retrospective study demonstrating an increased duration of gestation with increasing coital frequency at all gestational ages up through 37 weeks.8 Similarly, low - risk women delivering prematurely in another study were less likely to be sexually active than the full - term controls.10

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

Ludvigsson et al (32) examined 8300 infants and demonstrated that the duration of exclusive breast - feeding was not associated with a lower risk of atopic dermatitis, even among infants with a family history of atopy.

Research has found that women's breast cancer risk declines in inverse proportion to the duration of breastfeeding: That is, the longer you breastfeed your baby, the lower your risk for developing breast cancer.

Paragraph 2: Change to read: The shorter the duration of breastfeeding the greater the risk of respiratory and gastrointestinal infections and the greater the risk of hospitalization for lower respiratory disease.

Additionally, the U.S. Nurses» Health Study found only women with a lifetime duration of breastfeeding of 2 years or more had a significantly lower risk of coronary heart disease than those who never breastfed.

Breastfeeding is associated with about 10 % lower maternal risk of several major cardiovascular diseases (CVDs) in later life, and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding, according to a large, prospective, observational study among Chinese women.

Furthermore, duration and intensity of breastfeeding have also been found to relate to SIDS levels, with greater duration and intensity leading to a lower risk of SIDS [3].

Moreover, although this reduced the power of the multivariate analysis, the increased risk of low MDI and total IQ scores associated with a shorter duration of breast feeding persisted after adjustment for each of the confounders, including the Raven score.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

Iron supplementation resulted in an increased birth weight [5.3 ounces], gestational duration, and neonatal length; enhanced maternal and infant iron stores at 1 month after birth; and a decreased risk of low birth weight (by 58 percent) and prematurity.

Iron supplementation did result in increased birth weight, gestational duration, neonatal length, and a decreased risk of low birth weight and prematurity.

Further analysis found that the optimal sleep duration with the lowest risk of sickness absence from work was between 7 and 8 hours per night: 7 hours, 38 minutes for women and 7 hours, 46 minutes for men.

Physicians can reduce ODO by implementing such measures as screening for ODO risk factors when scheduling surgery and using the shortest duration and lowest effective doses possible.

Among patients who do receive opioids, the new Consensus Statement recommends prescribing the lowest effective doses for the shortest duration possible, based on recent studies that demonstrate opioids» risks increase with dosage.

The participants were asked to assume power pose for the duration of 2 minutes, which resulted in increased testosterone levels and lower presence of cortisol in their bloodstream, and greater preparedness for taking risks.

The bottom line: «The recommendation for hormone therapy is for the lowest effective dose for the shortest duration, to minimize the risk of breast cancer and to minimize risk overall,» sums up Dr. Manson.

But when they've done Step 1 and 2 of The Gottfried Protocol, I find that my patients need the lowest doses and shortest durations, making the risk lower.

Improving sleep quality and duration can lower the risk of obesity and even aid in resolving weight issues.

We are watching all of this play out real - time as fixed - income fund flows are broadly shunning sectors with embedded credit and / or duration risks, in favor of freshly attractive, and lower risk, high - carry assets.

This lowering of yields has exacerbated another challenge that already existed for traditional bond portfolios: the spread between duration and yield, which exacerbates interest rate risk.

In return for the greater risk, borrowers receive a lower initial rate than a fixed rate mortgage of the same amount and duration.

Dear Vishnu, Since you do have other sources of income and your risk profile for this investment is moderate, you may consider ultra short term or Short term Debt funds, conservative MIP fund... Ex: Franklin Ultra short / Franklin Low Duration Fund / SBI MIP Floater fund..

As a low duration strategy, the Fund offers limited interest - rate risk, as its average duration will not exceed three years.

If you mis - match the duration of your investments vs. when you will need the money, you run the risk of being a forced seller at a temporary market low.

Short - term muni bond investment strategies typically have the shortest duration targets and the lowest interest rate risk.

Rising rates could, over time, help restore the attractiveness of lower - risk government and shorter - duration debt — at the expense of more richly valued credit sectors that have benefited from the hunt for yield in recent years.

Compared to the Bloomberg Barclays Aggregate, the Balanced Risk Index aims to diversify the sources of risk and return, which has resulted in a tilt towards generating income and a more defensive (lower) duratRisk Index aims to diversify the sources of risk and return, which has resulted in a tilt towards generating income and a more defensive (lower) duratrisk and return, which has resulted in a tilt towards generating income and a more defensive (lower) duration.

These flows were directed mainly into lower risk exposures such as shorter duration bond ETFs and cash equivalent funds.

Low duration can mean less volatility or price risk.

While shortening duration can help mitigate interest rate risk, another approach to consider is one that balances exposure to the very front end of the curve with exposure to intermediate maturities for additional yield potential and lower volatility, given that rates are likely to rise slowly and stay historically low for the foreseeable future.

Low duration and the floating - rate structure of loans may help reduce interest - rate risk and lower portfolio volatility.

In today's low - rate environment, the risk - free rate is in the 0.03 % to 2.8 % range, depending on which Treasury instrument with a maturity from one month to 30 years is used (while many models use three - month T - bills, others may use T - notes or T - bonds depending on the duration of the analysis period).

The subsequent low - volatility screening is designed so that bonds with less risk, as demonstrated by their trading pattern, are selected, while duration and credit rating are held equal.

Lowest credit risk relative to other issuers / markets, but interest rate risk depends on the investment's duration.

Usually, yield is higher with these types of bond strategies than with short duration, while interest rate risk is lower than long duration.