Sentences with phrase «lox system»
The Cre / lox system is a well - established research tool, especially in the field of mouse transgenics.
http://blog.addgene.org/
The Cre - lox system is a technology that can be used to induce site - specific recombination events.
Have you used the Cre - lox system in your research?
Thus, T - DDOGs can be used in combination with green - red Cre - lox systems.
Not exact matches
The team was using a well - known Cre - lox genetic recombination system to get mouse neurons to express green, yellow, orange, and red fluorescent proteins.
The Saccharomyces cerevisiae FLP - FRT recombination system is another site - directed recombination technology very conceptually similar to Cre - lox, with flippase (Flp) and the short flippase recognition target (FRT) site being analogous to Cre and loxP, respectively.
These differences in recombinase efficiency are important to keep in mind when deciding whether to use the Cre - lox or one of the FLP - FRT systems in your experiments.
In 2007, Joshua Sanes and Jeff Lichtman, both of Harvard's Department of Molecular and Cellular Biology, harnessed these attributes of Cre - lox to create the Brainbow mouse neural labeling system.
To date, to create murine models, researchers use methods combining the Cre - Lox recombination system and the use of embryonic stem cells, but these processes are long and tedious, and it takes about 3 - 4 years to create a new mouse model.
In the normal workaday world of the body, this is no big deal, but when you overload the system it overcreates enzymes known as 5 - LOX, COX - 1 and COX - 2.
Research has demonstrated an inhibition of the 5 - LOX (lipoxygenase) system, involved in the enzymatic pathways that produce inflammatory molecules (leukotrienes and thromboxanes) from common fatty acids.