Ciba Animal Health won this battle in 1995 with the approval
of lufenuron for use in U.S. pets.
Products
with lufenuron do not include a flea - killing agent, only the sterilizer.
In order
for lufenuron and milbemycin to work against fleas, fleas must first bite the pet.
Technically, what
Lufenuron does is that it prevents the flea larvae from producing chitin which is a very important ingredient for the development of a very sturdy and very resilient outer shell.
Larvae that are able to hatch soon die and pre-existing larvae that
ingest lufenuron from feces of treated fleas also die.
If you have any questions or concerns
about lufenuron or how to treat flea infestations, contact your veterinarian.
Sentinel ™ is a new product by Novartis Animal Health US, Inc. which
combines lufenuron with milbemycin oxime.
As a later resort when yeast are a problem I am recommending an experimental treatment
called Lufenuron.
Some monthly chewable tablets
include lufenuron as a flea sterilizer in Program and may include mibemycin, as in Sentinel for additional internal parasites for total parasite control in one convenient form.
It should be recalled that Sentinel's
Lufenuron component is an insect growth inhibitor or insect development inhibitor.
Upset stomach, causing vomiting, diarrhea and decreased appetite May also cause itchiness, hives and red skin Lethargy and depression
Injectable lufenuron may cause injection site reactions (small lump under skin).
The flea life cycle becomes highly compromised by introducing
lufenuron into the system and since mammals do not make or need chitin, there is no effect on the pet.
Because
Lufenuron inhibits the production or synthesis of chitin, it is also deemed effective in the mitigation of fungal infections since about a third of the cell wall of fungal species is made of chitin.
In this article I describe
how Lufenuron works, dosing, and safety issues.
Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.
Selamectin lufenuron * is a once - monthly topical liquid applied to the skin at the back of the neck and sold as a preventative for heartworm and to control fleas (by preventing flea eggs from hatching, but it does not kill adults) plus sarcoptic and ear - mites in dogs.
This led to a great deal of research as to
whether lufenuron could prevent ringworm or might facilitate recovery from ringworm.
I will start using
lufenuron too and try to nip this problem once and for all.
There is another variant of Sentinel, the Sentinel Spectrum that provides an additional ingredient to its Milbemycin oxime and
Lufenuron formulation.
When adult fleas bite the dog, they eventually
suck Lufenuron into their own bloodstream and transfer the chemical to their growing eggs.
Combined, what you are looking for is a Milbemycin oxime -
Lufenuron blend of 4.6 mg and 91 mg.
Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas.
Lufenuron Orally: > 2,000 mg / kg in rats Milbemycin LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm and whipworm
infestations Lufenuron is an insect development inhibitor.
It interrupts the life cycle of the flea to prevent the continuing reproduction of new
generations Lufenuron and milbemycin flavored tablets are given by mouth May be given with nitenpyram (Capstar ®) to kill adult fleas.
The introduction of
lufenuron marked what is called the «revolution» in flea control where products shifted towards monthly oral and topical products and away from the labor - intensive materials of the past.
Oral lufenuron must be given on a full stomach in order to be properly absorbed into the body.
The average dosing
of Lufenuron is currently at 4.55 milligrams per pound of a dog's weight.
Another early IGR
called lufenuron (once monthly pills) inhibits the development of the exoskeleton of the flea and sterilizes the bug so it can't reproduce.